Cortisol, (hydrocortisone, compound F) is the primary glucocorticoid produced and secreted by the adrenal cortex in humans and other primates. It is often referred to as the “stress hormone” as it is involved in the response to stress, and affects blood pressure, blood sugar levels, and other actions of stress adaptation. Immunologically, cortisol functions as an important anti-inflammatory and plays a role in hypersensitivity, immunosuppression, and disease resistance. In the metabolic aspect, cortisol promotes gluconeogenesis, liver glycogen deposition, and the reduction of glucose utilization. Production of cortisol follows an ACTH-dependent circadian rhythm, with a peak level in the morning and decreasing levels throughout the day. Most serum cortisol, all but about 4%, is bound to proteins including corticosteroid binding globulin and serum albumin. It is already known that abnormal levels of cortisol are involved in Cushing’s Syndrome and Addision’s disease. Abnormal cortisol levels are also being evaluated for correlation with a variety of different conditions, such as prostate cancer, depression, and schizophrenia.
Arbor Assays is constantly revisiting it’s existing kits to make sure they continue to meet the needs of the research community. We are excited to announce an extended assay range for the DetectX Cortisol EIA Kit (K003-H), one of our most popular kits. In this case, no changes have been made to any of the core kit components. We’ve simply tested and validated an additional standard concentration increasing the range of the standard curve from 100 pg/ml- 3200 pg/ml to 50 pg/ml-3200pg/ml. We hope this improvement makes things easier for our customers, especially those hoping to detect lower levels of cortisol in their samples.