Arbor Assays is Pleased to Announce the World’s First Cyclic GAMP EIA Kit for
STING Signaling Research.
Coming in May 2018.
Cyclic GAMP EIA Kit, Catalog No: K067-H
- Use: Measure cGAMP in STING signaling
- Range: 50 pmol/mL – 0.205 pmol/mL
- Time to Answer: 2.5 hours
- Samples/Kit: 39 or 231 in duplicate
- Stability: Liquid, 4°C Stable Reagents
The innate immune system is the body’s crucial first defense against viral infections and it is dependent upon a group of pattern recognition receptors. cGMP-AMP Synthase (cGAS) responds to the presence of viral DNA in the cytosol by producing 2’,3’cGAMP. Cyclic GAMP in turn binds to STING leading to TBK1-mediated IRF3 activation and the production of type 1 IFN. Understanding the STING pathway and the role that cGAMP plays in the innate response to viral infection is of great interest as a possible mechanism for pharmaceutical intervention to treat cancer, lupus and infections.