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- Assay Type Competitive ELISA
- Sample Types Extracted Serum, Extracted Plasma, Urine, Fecal Extracts
- Sensitivity 1.85 pg/mL
- Species 11-Ketotestosterone is identical across species
- Assay Duration 2.5 Hours
- Samples/Plate 39 in duplicate
- Readout Colorimetric, 450 nm
- Standard Curve
Androgenic hormones, such as testosterone, affect the growth, size, and reproduction of many male organisms. In teleost fish, along with testosterone, 11-ketotestosterone plays a significant role by inducing reproductive characteristics in both males and females. In certain male fish, 11-ketotestosterone levels increase during spermatogenesis in spawning season, while in some female fish, 11-ketotestosterone increases prior to yolk deposition to regulate ovarian development.
The presence and involvement of 11-ketotestosterone in other species such as humans have only recently been established. In contrast to fish, primate serum 11-ketotestosterone concentrations were not significantly different in male and female, despite males having significantly higher circulating testosterone. This suggests that 11-ketotestosterone production in these species may not be testis-dependent and primarily originates from adrenal-derived 11-oxyandrogen precursors. Recent studies have discovered there is more 11-ketotestosterone than its precursors, androstenedione and testosterone, in prepubertal children and postmenopausal women compared to men. This highlights the potential use of 11-ketotestosterone as a clinical biomarker to screen adrenal androgen excess in disease conditions such as polycystic ovary syndrome (PCOS) and hirsutism in women.