Specifications

  • Sample Types Extracted Serum, Extracted Plasma, Urine, Fecal Extracts, Tissue Culture Media
  • Species 17HO-P is identical across species
  • Sensitivity 20.3 pg/mL
  • Time to Answer 1.5 Hours
  • Samples/Kit 40 or 232 in Duplicate
  • Stability Stable 4°C Liquid Reagents
  • Readout Colorimetric, 450 nm
  • Standard Curve
  • Description

    17-Hydroxyprogesterone is a steroid hormone belonging to the androgen group and is found and is in mammals, reptiles, birds, and other vertebrates. It was first isolated by Pfiffner and North in 1940. It is primarily produced in the adrenal glands but is also produced in the corpus luteum of the ovary. It is hydroxylated at the 11 and 21 positions to produce cortisol. A deficiency of either 11- or 21-hydroxylase results in decreased cortisol synthesis, and feedback inhibition of adrenocorticotropic hormone (ACTH) secretion is lost. Consequently increased pituitary release of ACTH will increase production of 17HO-P. However, if 17-alpha-hydroxylase or 3β-hydroxysteroid dehydrogenase type 2 is deficient, then 17HO-P levels will be low with either a possible increase in progesterone or pregnenolone respectively. Normal levels are 3-90 ng/dL in children. In women, normal levels are 20-100 ng/dL prior to ovulation, and 100-500 ng/dL during the luteal phase.

  • Structure