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Specifications

  • Assay Type Activity Assay
  • Sample Types Serum, Plasma (EDTA and Heparin), RBC Ghosts, Extracted Tissue Sample
  • Sensitivity 0.228 mU/mL
  • Species Human, Chicken, Mouse, Rat, Dog, Monkey, Pig
  • Assay Duration 20 Minutes
  • Samples/Plate 42 in Duplicate
  • Readout Fluorescent, 510 nm Emission / 390 nm Excitation
  • Standard Curve
  • Description

    Acetylcholinesterase (AChE) appears critical to both development and function of the nervous system. Acetylcholine (ACh) is an essential neurotransmitter in the central and peripheral nervous systems.  Impairment of cholinergic neurotransmission is well-established in Alzheimer’s disease, though the relevance early on as well as in mild cognitive impairment is contested. Other intentional or environmental impairment methods were found using organophosphates and carbamates with anticholinergic properties. The use of AChE inhibitors as therapeutic agents and pesticides has spurred detailed investigations of cholinesterases since their identification.