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- Assay Type Sandwich ELISA
- Sample Types Plasma
- Sensitivity 12.71 pg/mL
- Species Human
- Assay Duration 1.5 Hours
- Samples/Plate 40 in Duplicate
- Readout Colorimetric, 450 nm
- Standard Curve
Adrenocorticotropic hormone (ACTH, also adrenocorticotropin, corticotropin) is an important component of the hypothalamic-pituitary-adrenal axis (HPA) and is produced in response to biological stress. Its principal effects are increased production and release of glucocorticoids (GCs). Stress-induced secretion of the peptide hormone Corticotropin Releasing Hormone (CRH) stimulates pituitary ACTH secretion. Circulating ACTH binds to melanocortin receptors on the surface of adrenal zona cells, inducing the synthesis and release of all adrenal steroids, aldosterone, GCs and adrenal androgens. ACTH is also the principal modulator of cortisol and corticosterone. In addition to the stress response, ACTH synthesis is related to the circadian rhythm in many organisms. Measurement of plasma ACTH is helpful in the differential diagnosis of pituitary Cushing’s disease, Addison’s disease, adrenal tumors, adrenal hyperplasia, and ectopic ACTH syndrome.