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- Assay Type Competitive ELISA
- Sample Types Extracted Serum, Extracted Plasma (EDTA and Heparin), Urine, Saliva, Fecal Extracts, Tissue Culture Media
- Sensitivity 4.97 pg/mL
- Species Aldosterone is identical across species
- Assay Duration 2.5 Hours or Overnight
- Samples/Plate 40 in Duplicate
- Readout Colorimetric, 450 nm
- Standard Curve
Aldosterone is a mineralocorticoid first isolated by the husband and wife team of Simpson and Tait at University College, London. Aldosterone controls the sodium-potassium balance through unidirectional salt reabsorption in a variety of tissues and glands. Synthesized from cholesterol in the zona glomerulosa of the adrenal cortex, secretion is regulated through the renin-angiotensin system. Angiotensin II and potassium stimulate primary secretion by increasing the rate of production of the steroid. Peripheral aldosterone levels are dependent on age and body position. Aldosterone measurement is useful in the investigation of primary and secondary aldosteronism including vascular disease, salt depletion, potassium loading, cardiac failure with ascites, and pregnancy.