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- Sample Types Urine, Extracted Serum, Extracted Plasma (EDTA and Heparin), Dried Feces, Tissue Culture Media
- Species Allopregnanolone is identical across species
- Time to Answer 2.5 Hours or Overnight
- Range 10,000-156.3 pg/mL
- Samples/Kit 39 or 231 in Duplicate
- Cross Reactivity Low Cross Reactivity to Progesterone and Metabolites
- Readout Colorimetric, 450 nm
- Standard Curve
Allopregnanolone (3α-hydroxy-5α-pregnan-20-one, THP, THPROG) is a prototypic neurosteroid present in the blood and the brain. It is a metabolite of progesterone and potent modulator of GABAA receptors. Allopregnanolone has pharmacological properties including anxiolytic and anticonvulsant activity. The biosynthesis of allopregnanolone involves the conversion of progesterone into 5α-dihydroprogesterone by the enzyme 5α-reductase type I. Subsequently, 3α-hydroxysteroid oxidoreductase isoenzymes convert this intermediate into allopregnanolone. Anxiety and depression are common side effects of 5α-reductase inhibitors such as finasteride and dutasteride, and they are believed to be caused, in part, by the prevention of the endogenous production of allopregnanolone. Allopregnanolone aids neurogenesis and has been found to reverse neuron proliferative deficit and cognitive deficits in mouse models of Alzheimer’s disease.