Documentation

Product Protocol Product SDS
View Publications

Specifications

  • Assay Type Activity Assay
  • Sample Types Serum, Plasma (EDTA and Heparin)
  • Sensitivity 0.018 mU/mL
  • Species Human, Chicken, Mouse, Rat, Dog, Monkey, Pig
  • Assay Duration 20 Minutes
  • Samples/Plate 40 in Duplicate
  • Readout Fluorescent, 510 nm Emission / 390 nm Excitation
  • Standard Curve
  • Description

    Butyrylcholinesterase (BChE), found in the same structural class of proteins as acetylcholinesterase (AChE), is predominantly found in blood, kidneys, intestine, liver, lung, heart and the central nervous system. Species, such as human, horse and mice, exhibit high BChE plasma activity, whereas rats have higher acetylcholinesterase activity in plasma. In Alzheimer’s disease therapeutics, the use of potent cholinesterase inhibitors, acting on both AChE and BChE, protects limited endogenous acetylcholine levels found. As dementia advances, BChE activity has been shown to increase, while AChE activity decreases, leaving the potential for BChE activity to be used as a biomarker. BChE may also have roles in attention, executive function, emotional memory and behavior.