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Research Areas
Specifications
- Use Stress Marker in as Little as 1 µL Serum or Plasma
- Sample Serum, Plasma, Urine, Saliva, Fecal Extracts
- Validation Mice, Rats, Humans, Monkeys, Felids, Ungulates, Canine
- Time to Answer 2.5 Hours
- Samples/Kit 40 or 232 in Duplicate
- Stability Stable 4°C Liquid Reagents
- Readout Colorimetric, 450 nm
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Standard Curve
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Description
Cortisone (C21H28O5, Kendall’s Compound ‘E’) was identified by extraction from bovine suprarenal gland tissue. Cortisol and cortisone concentrations vary due to the activity of two 11β-hydroxysteroid dehydrogenases (11β-HSD). 11β-HSD1 is found primarily in the liver where it converts cortisone to cortisol while 11β-HSD2 is found in tissues such as the kidney where cortisol receptor binding is required. This glucocorticoid “shuttle” helps to initiate and regulate the anti-inflammatory response.