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- Assay Type Competitive ELISA
- Sample Types Serum, Plasma, Urine, Saliva, Fecal Extracts
- Sensitivity 29.0 pg/mL
- Species Cortisone is identical across species
- Assay Duration 2.5 Hours
- Samples/Plate 40 in Duplicate
- Readout Colorimetric, 450 nm
- Standard Curve
Cortisone (C21H28O5, Kendall’s Compound ‘E’) was identified by extraction from bovine suprarenal gland tissue. Cortisol and cortisone concentrations vary due to the activity of two 11β-hydroxysteroid dehydrogenases (11β-HSD). 11β-HSD1 is found primarily in the liver where it converts cortisone to cortisol while 11β-HSD2 is found in tissues such as the kidney where cortisol receptor binding is required. This glucocorticoid “shuttle” helps to initiate and regulate the anti-inflammatory response.