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- Assay Type Competitive ELISA
- Sample Types Serum, Plasma, Urine, Saliva, Fecal Extracts, Tissue Culture Media
- Sensitivity 90.9 pg/mL
- Species DHEA-S is identical across species
- Assay Duration 2.5 Hours
- Samples/Plate 41 in Duplicate
- Readout Colorimetric, 450 nm
- Standard Curve
Dehydroepiandrosterone sulfate (DHEA-S) is the major C19 steroid secreted by the adrenal cortex, and is a precursor to testosterone and estrogen biosynthesis. It is produced by the addition of a sulfate group to dehydroepiandrosterone (DHEA) catalyzed by the sulfotransferase enzymes, SULT1A1 and SULT1E1, which also produce estrone sulfate from estrone. Due to the presence of a 17-ketone group rather than a hydroxyl group, DHEA-S has relatively low androgenic activity. The bioactivity of DHEA-S may be high due to its serum concentrations being 100-1,000 -fold higher than testosterone or DHEA in addition to its weak affinity for sex-hormone binding globulin.