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- Sample Saliva, Urine, Fecal Extracts, Extracted Serum and Plasma, Tissue Culture Media
- Sensitivity 5.33 pg/mL
- Time to Answer 2.5 Hours or Overnight
- Samples/Kit 38 or 230 in Duplicate
- Readout Colorimetric, 450 nm
- Standard Curve
Estriol is one of the three major endogenous estrogens, along with estradiol and estrone. It is a weak estrogen derived from hydroxylation of estradiol and estrone in the liver. Normal levels in women who are not pregnant are typically nearly undetectable. However, estriol is produced in large amounts by the placenta and rising maternal levels can be detected from the very early weeks of pregnancy through until delivery. Estriol can be monitored as an indicator of fetal health and well-being during pregnancy. It is routinely measured as part of both the triple test and the quadruple test during pregnancy outreach and screening. Abnormally low levels in pregnant females can suggest chromosomal or congenital anomalies in the fetus. In some parts of the world exogenous estriol is used for the treatment of menopausal symptoms. Estriol has also been investigated as a protective neurosteroid with potential roles in immune diseases and bone and lipid metabolism.