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- Sample Fecal Extracts, Urine, Tissue Culture Media
- Sensitivity 22.4 pg/mL
- Time to Answer 2.5 Hours
- Recovery 93.7%
- Samples/Kit 39 or 231 in Duplicate
- Format 96-Well, Break-Apart Strip
- Stability Liquid 4°C Stable Reagents
- Readout Colorimetric, 450 nm
- Standard Curve
Kit provides a determination of inborn errors of sex steroid metabolism. Estrone, C18H22O2, is a C-18 steroid hormone and is one of the three naturally occurring estrogens; the others being estradiol and estriol. Estrone is produced primarily from androstenedione originating from the gonads or the adrenal cortex and from estradiol by 17-hydroxysteroid dehydrogenase. Androstenedione is also converted into estrone by aromatase (CYP19) to estrone and is expressed in stromal and carcinoma or parenchymal components of breast cancer tissue. Estrone concentrations in premenopausal mammals fluctuate according to the menstrual cycle. In premenopausal women, more than 50% of the estrone is secreted by the ovaries. In prepubertal children, men and non-supplemented postmenopausal women the major portion of estrone is derived from peripheral tissue conversion of androstenedione. Interconversion of estrone and estradiol also occurs in peripheral tissue.