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- Assay Type Detection Kit
- Sample Types Serum, Plasma, Urine, Buffers, Tissue Culture Media
- Sensitivity 0.413 mg/dL
- Species Human
- Assay Duration 30 Minutes
- Samples/Plate 40 in duplicate
- Readout Colorimetric, 560 nm
- Standard Curve
Glucose is by far the most common carbohydrate energy source for the cell. It is a monosaccharide, an aldose, a hexose, and a reducing sugar. It is also known as dextrose because it is dextrorotatory (rotates polarized light clockwise). For all biological and molecular events and for multiple cellular functions, energy is essential. Reduced energy levels threaten cellular homeostasis and integrity. Impaired energy metabolism may trigger pro-apoptotic signaling (programmed cell death), oxidative damage, or excitotoxicity and may impede mitochondrial DNA repair.
A serious drop in blood glucose can be characterized by metabolic dysfunction, neuroglycopenia, seizure, and death. A persistent elevation in blood glucose leads to “glucose toxicity.” Glucose toxicity contributes to β-cell dysfunction and the pathology grouped together as complications of diabetes. Estrogen-induced signaling pathways in hippocampal and cortical neurons involve the mitochondria to enhance mitochondrial function and to sustain aerobic glycolysis and citric acid cycle oxidative phosphorylation and ATP generation.