Specifications

  • Sample Serum, Plasma, Urine, Buffers, Tissue Culture Media
  • Time to Answer 30 minutes
  • Samples/Kit 88 in duplicate
  • Stability Liquid 4ºC stable reagents
  • Detection 560 nm
  • Standard Curve K039-H Standard Curve
  • Description

    Glucose is by far the most common carbohydrate energy source for the cell. It is a monosaccharide, an aldose, a hexose, and a reducing sugar. It is also known as dextrose because it is dextrorotatory (rotates polarized light clockwise). For all biological and molecular events and for multiple cellular functions, energy is essential. Reduced energy levels threaten cellular homeostasis and integrity. Impaired energy metabolism may trigger pro-apoptotic signaling (programmed cell death), oxidative damage, or excitotoxicity and may impede mitochondrial DNA repair.

    A serious drop in blood glucose can be characterized by metabolic dysfunction, neuroglycopenia, seizure, and death. A persistent elevation in blood glucose leads to “glucose toxicity.” Glucose toxicity contributes to β-cell dysfunction and the pathology grouped together as complications of diabetes. Estrogen-induced signaling pathways in hippocampal and cortical neurons involve the mitochondria to enhance mitochondrial function and to sustain aerobic glycolysis and citric acid cycle oxidative phosphorylation and ATP generation.