H-151 (941987-60-6) is a potent, irreversible inhibitor of Stimulator of Interferon Genes (STING) in mouse and human cells. H-151 covalently binds to Cys91 of STING preventing activation via blockade of palmitoylation and clustering STING. H-151 blocks STING induced expression of pro-inflammatory cytokines and reduces inflammation in models of auto-inflammatory disease.

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