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- Use Measure Pd contamination in 30 minutes
- Sample API scavenging steps
- Adaptable Suitable for HCl, NMP, MeCN, DMF, DMSO, EtOH, Toluene
- Simplified No acid digestion required
- Time to Answer 30 Minutes
- Samples/Kit 41 in Duplicate
- Stability Stable Room Temperature Liquid Reagents
- Readout Fluorescent, 520 nm Emission / 485 nm Excitation
- Standard Curve
Many new synthetic transformations, such as the Buchwald-Hartwig, Heck, Sonogashira, Suzuki-Miyaura, and Tsuji-Trost transformations, have been developed using palladium (Pd) compounds for the catalysis of carbon-carbon and carbon-heteroatom coupling reactions. These reactions are popular for pharmaceutical processes, as they utilize a wide-range of functional groups to build complicated molecules. However palladium-catalyzed reactions present a problem; the palladium can be retained in the isolated active pharmaceutical ingredient (API) product. Current FDA and EMEA regulations limit platinum group (Pt, Pd, Ir, Rh, Ru, Os) metal contamination, as a whole, to less than 5 ppm. Standard methods of Pd API evaluation, like atomic absorption analysis, x-ray fluorescence, and inductively-coupled plasma mass spectroscopy (ICP-MS), require expensive instrumentation and highly trained scientists to operate, suffer from probe cross-contamination, and require scrupulous clean up methodologies.