Specifications

  • Use Measure Pd contamination in 30 minutes
  • Sample API scavenging steps
  • Adaptable Suitable for HCl, NMP, MeCN, DMF, DMSO, EtOH, Toluene
  • Simplified No acid digestion required
  • Time to Answer 30 minutes
  • Samples/Kit 41 in Duplicate
  • Stability Stable RT Liquid Reagents
  • Readout Fluorescent, 520 nm emission/485 nm excitation
  • Standard Curve
  • Description

    Many new synthetic transformations, such as the Buchwald-Hartwig, Heck, Sonogashira, Suzuki-Miyaura, and Tsuji-Trost transformations, have been developed using palladium (Pd) compounds for the catalysis of carbon-carbon and carbon-heteroatom coupling reactions. These reactions are popular for pharmaceutical processes, as they utilize a wide-range of functional groups to build complicated molecules. However palladium-catalyzed reactions present a problem; the palladium can be retained in the isolated active pharmaceutical ingredient (API) product. Current FDA and EMEA regulations limit platinum group (Pt, Pd, Ir, Rh, Ru, Os) metal contamination, as a whole, to less than 5 ppm. Standard methods of Pd API evaluation, like atomic absorption analysis, x-ray fluorescence, and inductively-coupled plasma mass spectroscopy (ICP-MS), require expensive instrumentation and highly trained scientists to operate, suffer from probe cross-contamination, and require scrupulous clean up methodologies.