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- Assay Type Activity Assay
- Sample Types Serum, Plasma (EDTA and Heparin), Cell Lysates, RBCs
- Sensitivity 9 µU/mL
- Species Human
- Assay Duration 20 Minutes
- Samples/Plate 41 in Duplicate
- Readout Fluorescent, 510 nm emission / 370-410 nm excitation
- Standard Curve
Assay Principle: The DetectX® Glutathione Reductase (GR) Fluorescent Activity Kit is designed to quantitatively measure glutathione reductase (GR) activity in a variety of samples. Please read the complete kit insert before performing this assay.
Background: Glutathione reductase (GR) is a ubiquitous 100-120 kDa dimeric flavoprotein encoded by the GSR gene. It catalyzes the reduction of oxidized glutathione (GSSG) to reduced glutathione (GSH). GR plays an indirect role in the prevention of oxidative damage within the cell. GSH, in conjunction with glutathione peroxidase (GP), is the acting reductant responsible for minimizing harmful hydrogen peroxide. GSH dysregulation is correlated with diseases such as cancer, cystic fibrosis, and neurodegenerative diseases.