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- Sample Cell Lysates, Urine, Plasma, Saliva, Tissue, Tissue Culture Media
- Sensitivity 0.75 fmol/well
- Time to Answer 2 Hours
- Multi-Format Non-acetylated and acetylated assay options
- Convenient Lyse, Stabilize and Measure in One Step
- Samples/Kit 38 or 230 in Duplicate
- Stability Liquid 4°C Stable Reagents
- Readout Glow Luminescent
- Standard Curve
Adenosine-3’, 5’-cyclic monophosphate, or cyclic AMP (cAMP), is one of the most important second messengers and a key intracellular regulator. It was discovered by Sutherland and Rall in 1957. Cyclic AMP functions as a mediator of activity for a number of hormones, including epinephrine, glucagon, and ACTH. Adenylate cyclase is activated by the hormones glucagon and adrenaline, and by G protein. Liver adenylate cyclase responds more strongly to glucagon and muscle adenylate cyclase responds more strongly to adrenaline. cAMP decomposition into AMP is catalyzed by the enzyme phosphodiesterase. The Human Metabolome Database lists 166 metabolic enzymes that convert cAMP.