Specifications

  • Sample Cell Lysates, Urine, Plasma, Saliva, Tissue
  • Convenient Lyse, Stabilize and Measure in One Step
  • Sensitivity 4.2 fmol /well
  • Stability Liquid 4°C Stable Reagents
  • Samples/Kit 39 or 231 in Duplicate
  • Time to Asnwer 2.5 Hours
  • Readout Colorimetric, 450 nm
  • Standard Curve K019-Standard Curve
  • Description

    Adenosine-3’, 5’-cyclic monophosphate, or cyclic AMP (cAMP), is one of the most important second messengers and a key intracellular regulator. It was discovered by Sutherland and Rall in 1957. Cyclic AMP functions as a mediator of activity for a number of hormones, including epinephrine, glucagon, and ACTH. Adenylate cyclase is activated by the hormones glucagon and adrenaline, and by G protein. Liver adenylate cyclase responds more strongly to glucagon and muscle adenylate cyclase responds more strongly to adrenaline. cAMP decomposition into AMP is catalyzed by the enzyme phosphodiesterase. The Human Metabolome Database lists 166 metabolic enzymes that convert cAMP.

  • Structure cAMP Structure