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Documentation
Specifications
- Assay Type Sandwich ELISA
- Sample Types EDTA Plasma, Urine, Milk, Tissue Culture Media
- Sensitivity 0.246 ng/mL
- Species Human
- Assay Duration 2.5 Hours
- Samples/Plate 40 in Duplicate
- Readout Colorimetric, 650 nm and 450 nm
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Standard Curve
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Description
Osteopontin (OPN) has an important role in mineralization, blood vessel formation, cell survival, inflammation and inhibition of iNOS expression which protects tumor cells from NO-mediated macrophage cytotoxic attack. It also is a key molecule in neoplastic transformation and cancer development in a variety of tumors, playing a critical role in invasiveness, progression and metastasis. Plasma OPN has been shown to be a positive indicator of colon and lung cancers, as well as metastatic carcinomas. In addition, OPN mRNA expression increases approximately 40-fold in infarct tissue after a myocardial infarction.