• Use Measure OPN as a Breast and Prostate Cancer Marker
  • Sample Types EDTA Plasma, Urine, Milk, Tissue Culture Media
  • Standard Range 40-0.625 ng/mL with extended range option
  • Sensitivity 0.25 ng/mL
  • Samples/Kit 41 in Duplicate
  • Stability All Reagents Stable at 4ºC, except Osteopontin Standard (must be stored at -20ºC)
  • Time to Answer 2.5 Hours
  • Readout Colorimetric, 650 nm and 450 nm
  • Validated Published clinical validation data, Clin. Chem., 2009
  • Standard Curve
  • Description

    Osteopontin (OPN) has an important role in mineralization, blood vessel formation, cell survival, inflammation and inhibition of iNOS expression which protects tumor cells from NO-mediated macrophage cytotoxic attack. It also is a key molecule in neoplastic transformation and cancer development in a variety of tumors, playing a critical role in invasiveness, progression and metastasis. Plasma OPN has been shown to be a positive indicator of colon and lung cancers, as well as metastatic carcinomas. In addition, OPN mRNA expression increases approximately 40-fold in infarct tissue after a myocardial infarction.