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- Sample Types Serum, Plasma, Urine, Saliva
- Sensitivity 30 µg/dL
- Calibrated NIST Standard Reference #912a
- Time to Answer 30 Minures
- Samples/Kit 88 or 472 in Duplicate
- Stability Stable Room Temperature Liquid Reagents
- Readout Colorimetric, 450 nm
- Standard Curve
Urea is a by-product of protein metabolism by the liver, and is removed from the blood by the kidneys. Urea freely filters through the glomerulous, but is reabsorbed by the renal tubules in a flow-dependent fashion. The higher the flow rate, the greater amount of urea nitrogen is cleared from circulation and eliminated through the kidneys. As a result, the level of circulating urea nitrogen, along with serum creatinine, serves as a primary measure of kidney function. Normal adult blood urea nitrogen (BUN) levels should be between 7 and 21 mg urea nitrogen per 100 mL blood (mg/dL). Azotemia, poor kidney function, will cause elevated BUN levels (≥ 50 mg/dL) and is associated with acute kidney failure or injury, severe acute pancreatitis, congestive heart failure, or gastrointestinal bleeding. Azotemia also can occur with dehydration, as a result of alcohol abuse, or with high protein diets. Lower than expected BUN levels are usually not clinically predictive, but are primarily associated with liver disease or malnutrition, including malabsorption and low protein diets. Urine and saliva are considered to be acceptable non-invasive samples for measurement of urea nitrogen.