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Specifications
- Assay Type Competitive ELISA
- Sample Types Serum, Plasma (EDTA and Heparin), Saliva, Clarified Milk, Tissue Culture Media
- Sensitivity 17.0 pg/mL
- Species Oxytocin is identical across species
- Assay Duration Overnight Assay (16-18 hours)
- Samples/Plate 38 in Duplicate
- Readout Colorimetric, 450 nm
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Standard Curve
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Description
The neuropeptides oxytocin and vasopressin were isolated and synthesized by Vincent du Vigneaud, work for which he received the Nobel Prize in Chemistry in 1955. Oxytocin is a neurohypophysial peptide produced in the hypothalamus. The molecule consists of nine amino acids linked with a [1-6] disulfide bond and a semi-flexible carboxyamidated tail. Highly conserved across species boundaries, oxytocin-like neurohypophysial peptides are substituted primarily at residues 4 and/or 8. In the oxytocin-like peptide, mesotocin; a common peptide found in some fishes, reptiles, amphibians, marsupials and non-mammalian tetrapods, the leucine at residue 8 is substituted for isoleucine. Oxytocin binds to specific cell surface receptors, which in turn initiate a secondary intracelluar response cascade via a phosphoinositide signaling pathway. (K048)
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Structure
