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- Sample Serum, Plasma, Saliva, Clarified Milk, Tissue Culture Media
- Sensitivity 17.0 pg/mL
- Time to Answer Overnight Assay (16-18 hours)
- Cross Reactivity High Reactivity to Mesotocin (88.4%) and Isotocin (94.3%)
- Samples/Kit 38 or 230 in Duplicate
- Stability All Reagents Stable at 4ºC
- Readout Colorimetric, 450 nm
- Standard Curve
The neuropeptides oxytocin and vasopressin were isolated and synthesized by Vincent du Vigneaud, work for which he received the Nobel Prize in Chemistry in 1955. Oxytocin is a neurohypophysial peptide produced in the hypothalamus. The molecule consists of nine amino acids linked with a [1-6] disulfide bond and a semi-flexible carboxyamidated tail. Highly conserved across species boundaries, oxytocin-like neurohypophysial peptides are substituted primarily at residues 4 and/or 8. In the oxytocin-like peptide, mesotocin; a common peptide found in some fishes, reptiles, amphibians, marsupials and non-mammalian tetrapods, the leucine at residue 8 is substituted for isoleucine. Oxytocin binds to specific cell surface receptors, which in turn initiate a secondary intracelluar response cascade via a phosphoinositide signaling pathway. (K048)