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- Assay Type Sandwich ELISA
- Sample Types Serum, Plasma, Tissue Culture Media
- Sensitivity 30.5 pg/mL
- Species Human
- Assay Duration 3 Hours
- Samples/Plate 40 in Duplicate
- Readout Colorimetric, 450 nm
- Standard Curve
ST2 (also known as IL1RL1, DER4, T1 and FIT-1) is a member of the Toll-like/IL-1-receptor superfamily. The interleukin-1 (IL-1) receptor family has several members, including the classical interleukin-1 receptor (IL-1R) and the interleukin-18 receptor (IL-18R). In 1989, one member of the family, ST2, was identified as an orphan receptor. Investigation into the function of ST2 revealed its participation in inflammatory processes, particularly regarding mast cells, type 2 CD4+ T-helper cells, and the production of Th2-associated cytokines. ST2 was characterized as a specific cellular marker that differentiated Th2 from Th1 T-cells. The gene for ST2 spans ~40 kb on human chromosome 2q12, and is part of the larger human IL-1 gene cluster of ~200 kb. ST2 is conserved across species, with homologues in the genomes of mouse, rat, and fruitfly. The ~37 kDa unglycosylated secreted protein is converted into a 60–70 kDa glycosylated product, which is the soluble form of ST2, sST2.