The improved DetectX® Atrial Natriuretic Peptide (ANP) ELISA Kit (K071-H1/H5) from Arbor Assays provides a more sensitive and reliable method for precise quantitation of ANP in a wide range of sample types. The 96-well assay kit measures ANP in urine, plasma extracts, or tissue culture media using a competitive ELISA format in a 90 minute assay.
Improvements include:
- a new detection antibody formulation providing higher signal generation
- improved signal/background ratios
- stable, long-term supply of critical assay components
Atrial Natriuretic Peptide (ANP) is a critically important regulator of sodium and water balance, blood volume, and arterial blood pressure. It is synthesized and secreted by cardiac muscle cells in response to the expansion of arterial walls due to increased blood volume. ANP stimulates renal secretion of sodium and water and acts as a potent vasodilator. The combination of ANP actions effectively decreases blood volume, arterial pressure, cardiac output, and is a counter-regulator of the renin-angiotensin-aldosterone system. Pharmacological modulation of ANP is currently under investigation and synthetic homologues of ANP are being assessed for the treatment of hypertension and acute heart failure.