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Specifications
- Assay Type Competitive ELISA
- Sample Types Plasma, Urine, Tissue Culture Media
- Sensitivity 0.49 ng/mL
- Species Human, Pig, Sheep, Dog, Rat, Mouse
- Assay Duration 1.5 Hours
- Samples/Plate 40 in Duplicate
- Readout Colorimetric, 450 nm
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Standard Curve
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Description
Atrial natriuretic peptide (ANP), a peptide hormone secreted mostly by cardiac myocytes, is a potent natriuretic, diuretic and vasodilatory peptide that contributes to blood pressure and volume homeostasis. ANP is released by myocytes in response to atrial distension. Upon binding to cell surface receptors (NPR-A, B, and C, also termed guanylyl cyclase-A and B receptors), ANP acts through generation of cyclic guanosine monophosphate (cGMP). Atrial natriuretic peptide demonstrates hemodynamic and glomerular effects, which increase sodium and water load delivery to the tubules, and the inhibition of the release of renin, aldosterone and vasopressin.
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Structure
