• Sample Types Plasma, Urine, Tissue Culture Media
  • Time to Answer 90 Minutes
  • Simple 2 Step Assay
  • Samples/Kit 40 or 232 in Duplicate
  • Stability Liquid 4°C Stable Reagents
  • Readout Colorimetric, 450 nm
  • Standard Curve
  • Description

    Atrial natriuretic peptide (ANP), a peptide hormone secreted mostly by cardiac myocytes, is a potent natriuretic, diuretic and vasodilatory peptide that contributes to blood pressure and volume homeostasis. ANP is released by myocytes in response to atrial distension. Upon binding to cell surface receptors (NPR-A, B, and C, also termed guanylyl cyclase-A and B receptors), ANP acts through generation of cyclic guanosine monophosphate (cGMP). Atrial natriuretic peptide demonstrates hemodynamic and glomerular effects, which increase sodium and water load delivery to the tubules, and the inhibition of the release of renin, aldosterone and vasopressin.

  • Structure