2′,3′-Cyclic GAMP ELISA Kit


  • Most Sensitive
  • Use - Measure 2',3'-cGAMP in tissues and cells
  • Sample - Cell Lysates, Tissue Extracts, TCM
  • Samples/Kit - 39 or 231 in Duplicate
  • Sensitivity - 0.04 pmol/mL, 2 fmol/well
  • Stability - Liquid 4˚C Stable Reagents

View Publications

2’,3’-Cyclic guanosine monophosphate–adenosine monophosphate (cyclic GMP-AMP, cGAMP, cyclic [G(2’,5’)pA(3’,5’)p]) was the first cyclic di-nucleotide found in metazoa. 2’,3’-cGAMP is also referred to as “noncanonical“ cGAMP due to the presence of the atypical 2’-5’ phosphodiester linkage between the guanosine and the adenosine. 2’,3’-Cyclic GAMP is a novel second messenger in innate immunity that regulates type I interferon (IFN) production. Produced in mammalian cells by cGAS (cGAMP synthase) in response to double-stranded DNA in the cytoplasm binding to cGAS, cGAMP binds to the stimulator of interferon genes (STING). Subsequently STING induces the TBK1-IRF3-dependent production of IFN-β. This cGAS-cGAMP-STING pathway has been shown to play a critical role in pathogen detection and physiological conditions such as metabolic dysregulation, autoimmunity, and cancer.

Data Reduction Template by MyAssays

View All Publications

+ Publications 8 total publications

G-quadruplex binders as cytostatic modulators of innate immune genes in cancer cells

Jun 17 2021 | (SPECIES: Human, SAMPLE: Cell Extracts)

CGAS is a micronucleophagy receptor for the clearance of micronuclei

Mar 22 2021 | (SPECIES: Human, SAMPLE: Cell Lysate)

ER-directed TREX1 limits cGAS activation at micronuclei

Jan 20 2021 | (SPECIES: Micronuclei, SAMPLE: Cell Lysate)

Attenuation of cGAS/STING Activity During Mitosis

Dec 20 2019 | (SPECIES: Human, SAMPLE: Cell Lysate)

Tight nuclear tethering of cGAS is essential for preventing autoreactivity

Dec 06 2019 | (SPECIES: Human, SAMPLE: Cell Lysates)

Subscribe to our mailing list

Sign up to our e-mail newsletter and receive updates and special offers.