Research Areas

Documentation

Product Protocol Product SDS

Specifications

  • Sample Types Serum, Plasma (EDTA and Heparin), Urine, Tissue Culture Media
  • Samples/Kit 40 in Duplicate
  • Stability Liquid 4°C Stable Reagents
  • Sensitivity 58 pg/mL
  • Time to Answer 2 Hours
  • Readout Colorimetric, 450 nm
  • Standard Curve
  • Description

    Cystatin C is a non-glycosylated protein of low molecular weight (13 kDa) in the cystatin superfamily. It is produced at a constant rate in all nucleated cells and then secreted, and thus is found in most body fluids. Cystatin C belongs to the cysteine proteinase inhibitor group and is associated with several pathological states. Imbalance between Cystatin C and cysteine proteinases is associated with conditions such as inflammation, renal failure, cancer, Alzheimer’s disease, multiple sclerosis, and hereditary Cystatin C amyloid angiopathy. Cystatin C is removed from blood plasma by glomerular filtration in the kidneys. It is reabsorbed by the proximal tubular cells and degraded. There is a linear relationship between the reciprocal Cystatin C concentration in plasma and the glomerular filtration rate (GFR). Cystatin C is suggested to be a better marker for GFR than serum creatinine as its serum concentration is not affected by factors such as age, gender and body mass. There is association of Cystatin C levels with the incidence of myocardial infarction, coronary death and angina pectoris, presenting a risk factor for secondary cardiovascular events.