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- Sample Types Serum, Plasma (EDTA and Heparin), Urine, Tissue Culture Media
- Samples/Kit 40 in Duplicate
- Stability Liquid 4°C Stable Reagents
- Sensitivity 58 pg/mL
- Time to Answer 2 Hours
- Readout Colorimetric, 450 nm
- Standard Curve
Cystatin C is a non-glycosylated protein of low molecular weight (13 kDa) in the cystatin superfamily. It is produced at a constant rate in all nucleated cells and then secreted, and thus is found in most body fluids. Cystatin C belongs to the cysteine proteinase inhibitor group and is associated with several pathological states. Imbalance between Cystatin C and cysteine proteinases is associated with conditions such as inflammation, renal failure, cancer, Alzheimer’s disease, multiple sclerosis, and hereditary Cystatin C amyloid angiopathy. Cystatin C is removed from blood plasma by glomerular filtration in the kidneys. It is reabsorbed by the proximal tubular cells and degraded. There is a linear relationship between the reciprocal Cystatin C concentration in plasma and the glomerular filtration rate (GFR). Cystatin C is suggested to be a better marker for GFR than serum creatinine as its serum concentration is not affected by factors such as age, gender and body mass. There is association of Cystatin C levels with the incidence of myocardial infarction, coronary death and angina pectoris, presenting a risk factor for secondary cardiovascular events.