Aldosterone is a steroid hormone primarily involved in the regulation of sodium and potassium levels in blood as part of the renin-angiotensin system (RAS). Aldosterone increases reabsorbation of sodium from the tubular epithelial cells of kidneys back into the blood, while at the same time moving potassium ions from the blood into the kidneys for eventual excretion in urine. Unusually high levels of aldosterone (hyperaldosteronism) lead to elevated blood sodium and reduced blood potassium; increasing water retention, blood pressure and blood volume. These in turn contribute to the development and progression of both cardiovascular and renal disease. Drugs that interfere with either the secretion or function of aldosterone are in clinical use as antihypertensives. For example, Lisinopril blocks the action of angiotensin-converting enzyme, reducing secretion of aldosterone. The treatment goal for these drugs is to reduce water retention and blood pressure while preventing the loss of potassium.
Measuring aldosterone and ET-1 can potentially be useful in identifying the cause(s) of high blood pressure so optimal treatment can be offered and for monitoring the efficacy of treatment. In addition to blood pressure, aldosterone has roles in kidney disease, heart failure, diabetic neuropathy and other diseases.
The DetectX® Aldosterone Enzyme Immunoassay (EIA) Kit (K052-H1/H5) and Chemiluminescent Immunoassay (CLIA) Kit (K052-C1/C5) are designed to quantitatively measure aldosterone present in extracted serum and plasma, urine, extracted fecal samples, and tissue culture media samples. Our EIA and CLIA kits feature liquid reagents that are stable at 4°C. For each kit, an aldosterone stock solution is provided to generate a standard curve. The kits allow samples to be measured from 5000 to 3.9 pg/mL for the EIA and from 1500 to 2.06 pg/mL for the CLIA.
DetectX® ET-1 EIA Kit – Catalog No. K045-H
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DetectX® Urinary Retinol Binding Protein EIA Kit – Catalog No. KU04-H1
DetectX® Urea Nitrogen (BUN) Detection Kits – Catalog No. K024-H
DetectX® Hemoglobin Colorimetric Detection Kit – Catalog No. K013-H1