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- Assay Type Sandwich ELISA
- Assay Duration 2.5 Hours
- Standard Range 1.25 - 80 pg/mL
- Sample Types Serum and EDTA Plasma
- Sensitivity 0.31 pg/mL
- Samples/Kit Up to 40 or 232 samples in duplicate
- Stability -20°C Stability, Liquid Reagents
- Readout Colorimetric, 450 nm
- Standard Curve
B-Type Natriuretic Peptide (BNP [formerly known as brain natriuretic peptide]) is an important hormone that regulates blood pressure and volume. In patients with heart failure, increased heart stretch or hypoxia can trigger BNP synthesis and secretion from ventricular cardiomyocytes, as opposed to its normal constitutive release from only the atrium. Upon secretion, proBNP is cleaved into active BNP (32 amino acids), having a half-life of 20 minutes, and inactive NT-proBNP (76 amino acids), having a half-life of 90 minutes. BNP serum levels are greatly elevated in patients suffering from heart failure and cardiac dysfunction, so this biomarker is a great addition to the diagnostic criteria for these diseases. Patients with serum concentrations greater than 100 pg/mL of BNP are very likely to suffer from heart failure or cardiac dysfunction. Not only can you determine the diagnostic outcome from this biomarker, but you can also monitor treatment efficacy for patients suffering from heart failure or cardiac dysfunction.