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- Assay Type Sandwich ELISA
- Sample Types Serum, Platelet-Poor Heparin Plasma, Saliva, Urine, Tissue Culture Media
- Sensitivity 68 pg/mL
- Species Human
- Assay Duration 2.5 Hours
- Samples/Plate 40 in duplicate
- Readout Colorimetric, 450 nm
- Standard Curve
Myeloperoxidase (MPO) is a tetrameric heme-containing protein abundantly produced in neutrophil granulocytes where it plays an important anti-microbial role. Normally stored in azurophilic granules, MPO is released into the extracellular space during degranulation. There, as part of the neutrophils “respiratory burst”, it produces hypochlorous acid from hydrogen peroxide and Cl- . MPO also uses hydrogen peroxide to oxidize tyrosine to the tyrosyl radical. Both hypochlorous acid and tyrosyl are cytotoxic and when present can kill bacteria and other pathogens. Hereditary deficiency of myeloperoxidase predisposes individuals to immune deficiency.
Studies have shown an association between elevated MPO levels and coronary artery disease, and in 2003 it was suggested that MPO may serve as a sensitive predictor of myocardial infarction in patients complaining of chest pain. Since that time the clinical utility of MPO testing in cardiac patients has been solidly established in the literature with well over 100 papers published. In 2010 this clinical application was further refined by additional studies which determined that measuring both MPO and C-reactive protein (CRP) provided more accurate prediction of mortality risk than measuring just CRP alone.
Athens Research and Technology Reagents