Chronic Stress & PTSD
Chronic repeated unpredictable stress induces PTSD in mice… and likely humans, too. Chronic stress can lead to dysregulation of hypothalamic-pituitary-adrenal (HPA)...
Advances in Non-Invasive Hormone Monitoring
Corticosterone & Non-Invasive Sample Types Corticosterone—the most common glucocorticoid in rodent animal models of stress—is easily measured using ELISA techniques....
Dietary Antioxidants: Using Diets to Reduce Stress
Reactive Oxygen Species (ROS) can react with vital macromolecules, damaging biomolecules critical to cellular structure and function. Antioxidants protect biological...
Neonatal Stress Alters Adult Behavior and Stress Reactivity
Early-life stressful experiences can have negative consequences on brain maturation. To understand the long-term implications of neonatal stress, researchers from...
Dinural Glucocorticoid Hormone Response
“Glucocorticoid hormones are secreted with a prominent daily rhythm, but their diurnal genomic actions remain uncharacterized. Quagliarini et al. show...
Even Gentle Restraints Can Increase Stress in Lab Mice
The C57BL/6 mouse strain, also known as “black 6”, was developed at the Bussey Institute from C.C. Little’s C57BL strain...
Can Raw Cane Sugar Help Reduce Stress?
Japanese researchers observe anti-stress and antioxidant effects of raw cane sugar. Modern life can be somewhat stressful and excessive...
Binge Drinking and Future Progeny
It is well documented that alcohol during pregnancy can cause complications for pregnancy and birth, but little is known about...
Validation of 8 Assays in 8 Species of Whales
Even with significant protections in place, whale populations continue to be low relative to apparent historic norms. Unfortunately, the reasons...
Fecal Corticosterone Assessment in Socially Housed Lab Animals
A great deal of attention is paid to glucocorticoid levels in connection with the conservation of animal species in the...
Sleep Disruption and Glucose Tolerance
Sleep disturbances, including sleep fragmentation, are known to occur more frequently in individuals with type 2 diabetes than in the...
Immune-Mediated Arthritis and the HPA Axis
Acute inflammation is commonly associated with activation of the HPA axis leading to higher levels of circulating glucocorticoids. However, studies...