At the National Institutes of Health (NIH) in Washington D.C., researchers are pushing the boundaries of health science, developing key insights into diseases, treatments, and overall human health. The work done here impacts global health initiatives and shapes future medical practices. Arbor Assays is proud to be a trusted partner in this effort, providing reliable and high-quality assay kits that assist with health research at the NIH and its researchers in their critical investigations.
Check out just five examples in research journals that highlight how NIH scientists are using Arbor Assays kits in their studies. From exploring the mechanisms of stress responses to investigating liver disease, these are just a few published examples of how our kits play an integral role in advancing medical knowledge.
1. Single-Cell Resolution and Quantitation of Targeted Glucocorticoid Delivery in the Thymus
Journal: Cell Reports
Year: 2019
Kit Used: Corticosterone Chemiluminescent ELISA Kits
This study focused on how thymic epithelial cells (TEC) deliver glucocorticoids to specific T-cell subsets in the thymus. Researchers found that CD4(+)CD8(+)TCR(hi) cells, which undergo selection, are exposed to significantly higher glucocorticoid levels than other cells, showing how local hormone signaling can be precisely targeted. Arbor Assays’ Corticosterone Chemiluminescent ELISA Kit was used to quantify these hormone levels, allowing researchers to track glucocorticoid exposure with high accuracy. Read more
2. Tartary Buckwheat Extract Alleviates Alcohol-Induced Liver Injuries
Journal: American Journal of Translational Research
Year: 2020
Kit Used: Glutathione (GSH) Colorimetric Detection Kit
A team of researchers examined the protective effects of tartary buckwheat extract (TBE) on alcohol-induced liver damage. Using Arbor Assays’ Glutathione (GSH) Colorimetric Detection Kit, they measured improvements in liver health, finding that TBE alleviated liver injury by inhibiting oxidative stress and preventing mitochondrial cell death. This study highlights potential therapeutic uses for natural extracts in treating liver disease. Read more
3. Cushing Syndrome in a Pediatric Patient with a KCNJ5 Variant
Journal: Journal of Clinical Endocrinology & Metabolism
Year: 2021
Kit Used: Cortisol ELISA Kits
In this case study, a young patient with Cushing Syndrome (CS) was found to have a novel KCNJ5 variant. The use of Arbor Assays’ Cortisol ELISA Kit enabled researchers to monitor cortisol levels and assess the effectiveness of low-dose ketoconazole in controlling CS symptoms. The findings suggest that GIRK4 potassium channels may play a previously unknown role in adrenal development and disease. Read more
4. Tumors Produce Glucocorticoids via Metabolite Recycling
Journal: J Clin Invest
Year: 2023
Kit Used: Corticosterone Multi-Format ELISA Kits
Researchers explored how tumors produce glucocorticoids to activate regulatory T cells (Tregs) and promote tumor growth. Using Arbor Assays’ Corticosterone Multi-Format ELISA Kits, researchers discovered that tumors recycle inactive glucocorticoid metabolites, contributing to immune suppression. These results offer potential strategies for targeting tumor metabolism to enhance cancer treatments. Read more
5. Lower Hair Cortisol Among Patients with Sickle Cell Disease
Journal: American Journal of Blood Research
Year: 2021
Kit Used: Cortisol ELISA Kits
While investigating stress responses in patients with sickle cell disease (SCD), researchers found that lower hair cortisol levels may indicate adrenal insufficiency in these patients. Using Arbor Assays’ Cortisol ELISA Kit, the study revealed links between cortisol levels, hemoglobin S, and the severity of SCD. What this might suggest is that cortisol measurements could help identify SCD patients at risk for adrenal complications. Read more
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Health Research at the NIH show their dedication to advancing medical research which is undeniable, and we at Arbor Assays are proud to contribute to this mission. Our high-performance assay kits help researchers uncover new insights into human health and disease, accelerating progress in both national and global healthcare. Explore our full range of products and see how Arbor Assays can support your research needs today.