Reach out! We’re available by email or phone and can answer all of your questions.
You can also reference the ordering page for more information.
Documentation
Specifications
- Features Potent histone acetyltransferases inhibitor
- Induces HeLa cell apoptosis
- Anti-inflammatory and anti-carcinogenic
-
Description
Garcinol is an inhibitor of the histone acetyltransferases (HATs) p300 and PCAF with IC50 of 7 and 5 uM, respectively. It also inhibits the HAT GCN5 in Cryptococcus neoformans, inducing temperature sensitivity and impairing growth. A polyisoprenylated benzophenone isolated from Garcinia indica, garcinol promotes neurogenesis and ex vivo expansion of human hematopoietic stem cells. It induces apoptosis in several types of cancer cells and has anti-inflammatory actions.
-
Structure
