Showing 1–16 of 25 results
5-Azacytidine
Incorporates into DNA, forming covalent adducts with cellular DNMT1, depleting enzyme activity. Induces demethylation and reactivation of silenced genes. Improves…
Specifications
Pricing
Features
DNA Methyltransferase inhibitor
Blocks cell cycle progression at G1
Induces activation of HIV-1 promoter
P012-50MG 5-Azacytidine, 50 mg $ 30.00
P012-250MG 5-Azacytidine, 250 mg $ 112.00
Apicidin
Potent inhibitor of histone deacetylase (HDAC) activity and proliferation. Induces cell cycle arrest at the G1 phase. At 100 nM…
Specifications
Pricing
Features
Potent HDAC Inhibitor
Blocks Cell Cycle G1
HIV-1 Promoter
P011-1MG Apicidin, 1 mg $ 83.00
P011-5MG Apicidin, 5 mg $ 336.00
BIX-01294
BIX-01294, a diazepin-quinazolinamine derivative, is a selective,cell-permeable G9a-like protein and G9a histone lysine methyltransferase (HMTase) inhibitor (IC50 values are 0.7…
Specifications
Pricing
Features
Inhibitor of G9a and GLP HMTases
Cell permeable
Selectively impairs generation of Histone H3K9me2
P018-5MG BIX-01294, 5 mg $ 89.00
P018-25MG BIX-01294, 25 mg $ 348.00
BML-210
Inhibition of histone deacetylase (HDAC) enzymes by compounds such as trichostatin A can have wide ranging effects in cancer, cell…
Specifications
Pricing
Use
Potent HDAC Inhibitor
Increases A549 acetylated histone levels
Inhibits transcription factor FOXO3 by SIRT
P013-5MG BML-210, 5 mg $ 130.00
P013-25MG BML-210, 25 mg $ 460.00
BML-278
Sirt activator based on a dihydropyridine structural scaffold. EC150 (effective concentration able to increase enzyme activity by 150%) is 1…
Specifications
Pricing
Features
Novel SIRT activator
Dihydropyridine scaffold
Arrests cell cycle at G1/S phase
P003-5MG BML-278, 5 mg $ 94.00
P003-25MG BML-278, 25 mg $ 378.00
Features
Potent Inhibitor of PDE7
Induces apoptosis
Cell permeable
Room temperature storage
P020-10MG BRL-50481, 10 mg $ 100.00
P020-50MG BRL-50481, 50 mg $ 425.00
C-646
A reversible, cell-permeable pyrazolone p300/CBP HAT inhibitor (Ki = 400 nM), which competes with acetyl-CoA for the p300 Lys-CoA binding…
Specifications
Pricing
Features
p300/CBP HAT inhibitor
Inhibits melanoma cancer cell growth
Less than 10% inhibition of other HATs
Storage at 4°C
P014-5MG C-646, 5 mg $ 130.00
P014-25MG C-646, 25 mg $ 561.00
Decitabine
Cytosine analog, that when incorporated into DNA, acts as a suicide substrate for DNA methyltransferase. Inhibits DNA methyltransferase and results…
Specifications
Pricing
Features
DNA Methyltransferase inhibitor
Hypomethylating agent
Inhibits melanoma cancer cell growth
Storage at 4˚C
P015-10MG Decitabine, 10 mg $ 148.00
P015-50MG Decitabine, 50 mg $ 531.00
DMXAA
DMXAA is a STING (Stimulator of Interferon Genes) agonist selective for mouse STING.
Specifications
Pricing
P024-5MG DMXAA, 5 mg $ 176.00
P024-25MG DMXAA, 25 mg $ 660.00
EX-527
EX-527 is a cell-permeable, selective inhibitor of SIRT1 (IC50 = 98 nM in vivo, 38nM in vitro) that does not…
Specifications
Pricing
Features
Selective SIRT1 inhibitor
Does not inhibit HDACs
Inhibitor of SIRT1 deacetylation of p53
P005-5MG EX-527, 5 mg $ 106.00
P005-25MG EX-527, 25 mg $ 378.00
FK-866 HCl
FK-866 is a selective inhibitor of the nicotinamide pathway dependent NAD+ synthesis, causing NAD+ depletion. Highly specific, non-competitive inhibitor of…
Specifications
Pricing
Features
Specific inhibitor of NAMPT
Indirect inhibitor of SIRT1
Causes gradual NAD+ depletion
P006-5MG FK-866 HCl, 5 mg $ 171.00
P006-25MG FK-866 HCl, 25 mg $ 531.00
Garcinol
Garcinol is an inhibitor of the histone acetyltransferases (HATs) p300 and PCAF with IC50 of 7 and 5 uM, respectively….
Specifications
Pricing
Features
Potent histone acetyltransferases inhibitor
Induces HeLa cell apoptosis
Anti-inflammatory and anti-carcinogenic
P017-5MG Garcinol, 5 mg $ 71.00
P017-25MG Garcinol, 25 mg $ 260.00
H-151
H-151 (941987-60-6) is a potent, irreversible inhibitor of Stimulator of Interferon Genes (STING) in mouse and human cells.
Specifications
Pricing
P023-10MG H-151, 10 mg $ 140.00
P023-50MG H-151, 50 mg $ 530.00
Hexyl-4-pentynoic acid (HPA)
HPA causes histone hyperacetylation and protect against glutamate induced excitotoxicity in cultured neurons. HPA is one of the most effective…
Specifications
Pricing
Features
Induces histone hyperacetylation
30 times lower IC50 than VPA
Protects against glutamate-induced excitotoxicity
Exclusive product
P008-10MG Hexyl-4-pentynoic acid (HPA), 10 mg $ 71.00
P008-50MG Hexyl-4-pentynoic acid (HPA), 50 mg $ 283.00
IBMX
IBMX is a widely-used non-specific inhibitor of cyclic AMP and cyclic GMP phosphodiesterases (PDEs) with IC50s from 7 to 50…
Specifications
Pricing
Features
Pan-specific inhibitor of PDEs
Increases cellular cAMP and cGMP
Activates protein kinases
Storage at room temperature
P019-100MG IBMX, 100 mg $ 47.00
P019-1GM IBMX, 1 gm $ 212.00
IOX1
Inhibits the JMJD family of 2-oxoglutarate-dependent histone demethylases. IC50 = 0.12, 0.07, 0.2, 0.3, 0.6, and 1 μM for JMJD3,…
Specifications
Pricing
Features
Inhibitor of Jumonji HDMs
Broad spectrum 2-oxoglutarate oxygenase inhibitor
Cell Permeable
P022-5MG IOX1, 5 mg $ 142.00
P022-25MG IOX1, 25 mg $ 561.00
