Inhibitors & Activators

BIX-01294, a diazepin-quinazolinamine derivative, is a selective,cell-permeable G9a-like protein and G9a histone lysine methyltransferase (HMTase) inhibitor (IC50 values are 0.7…

Binds to the N-terminal domain of valosin-containing protein (VCP), an essential protein for autophagosome maturation. Xanthohumol inhibits the function of…

Trichostatin A is a potent, reversible inhibitor of histone deacetylase (HDAC) with a Ki of 3.4 nM. In human Jurkat…

Inhibitor of prostacyclin synthase1, monoamine oxidase inhibitor. Also an inhibitor of LSD1, a histone H3 demethylase (IC50>2uM). Treatment of P19…

An anticonvulsant used in the treatment of epilepsy, anorexia nervosa, panic attack, anxiety disorder, post traumatic stress disorder, migraine and…

Cell-permeable, selective sirtuin deacetylase inhibitor (IC50 values are 38, 68 and 131 uM for SIRT2, Sir2p and SIRT1 respectively) that…

SAHA (suberoylanilide hydroxamic acid, Vorinostat, Zolinza™) is a histone deacetylase (HDAC) inhibitor that binds directly to the catalytic site of…

Potent SIRT1 activator and a phytoestrogen with antitumor, antioxidant, antiplatelet, anti-inflammatory and antifungal effects. Inhibits cytochrome P450 1A1 (IC50 =…

Activator of human deacetylase SIRT1. Anti-inflammatory, immunomodulatory and antiproliferative agent that inhibits p56lck and syk protein tyrosine kinases and inhibits…

Histone deacetylase inhibitor that displays anticancer activity. Inhibits cell proliferation, invasion and migration and induces apoptosis in glioma cells. Also…

Inhibits the JMJD family of 2-oxoglutarate-dependent histone demethylases. IC50 = 0.12, 0.07, 0.2, 0.3, 0.6, and 1 μM for JMJD3,…

IBMX is a widely-used non-specific inhibitor of cyclic AMP and cyclic GMP phosphodiesterases (PDEs) with IC50s from 7 to 50…

HPA causes histone hyperacetylation and protect against glutamate induced excitotoxicity in cultured neurons. HPA is one of the most effective…

H-151 (941987-60-6) is a potent, irreversible inhibitor of Stimulator of Interferon Genes (STING) in mouse and human cells.

Garcinol is an inhibitor of the histone acetyltransferases (HATs) p300 and PCAF with IC50 of 7 and 5 uM, respectively….

FK-866 is a selective inhibitor of the nicotinamide pathway dependent NAD+ synthesis, causing NAD+ depletion. Highly specific, non-competitive inhibitor of…