Showing 1–16 of 25 results

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5-Azacytidine

Incorporates into DNA, forming covalent adducts with cellular DNMT1, depleting enzyme activity. Induces demethylation and reactivation of silenced genes. Improves…

P012-50MG 50-mg - $25.00
P012-250MG 250-mg - $95.00

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Apicidin

Potent inhibitor of histone deacetylase (HDAC) activity and proliferation. Induces cell cycle arrest at the G1 phase. At 100 nM…

P011-1MG 1-mg - $70.00
P011-5MG 5-mg - $285.00

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BIX-01294

BIX-01294, a diazepin-quinazolinamine derivative, is a selective,cell-permeable G9a-like protein and G9a histone lysine methyltransferase (HMTase) inhibitor (IC50 values are 0.7…

P018-5MG 5-mg - $75.00
P018-25MG 25-mg - $295.00

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BML-210

Inhibition of histone deacetylase (HDAC) enzymes by compounds such as trichostatin A can have wide ranging effects in cancer, cell…

P013-5MG 5-mg - $110.00
P013-25MG 25-mg - $390.00

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BML-278

Sirt activator based on a dihydropyridine structural scaffold. EC150 (effective concentration able to increase enzyme activity by 150%) is 1…

P003-5MG 5-mg - $80.00
P003-25MG 25-mg - $320.00

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P020-10MG 10-mg - $85.00
P020-50MG 50-mg - $360.00

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C-646

A reversible, cell-permeable pyrazolone p300/CBP HAT inhibitor (Ki = 400 nM), which competes with acetyl-CoA for the p300 Lys-CoA binding…

P014-5MG 5-mg - $110.00
P014-25MG 25-mg - $475.00

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Decitabine

Cytosine analog, that when incorporated into DNA, acts as a suicide substrate for DNA methyltransferase. Inhibits DNA methyltransferase and results…

P015-10MG 10-mg - $125.00
P015-50MG 50-mg - $450.00

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DMXAA

DMXAA is a STING (Stimulator of Interferon Genes) agonist selective for mouse STING.

P024-5MG 5-mg - $149.00
P024-25MG 25-mg - $559.00

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EX-527

EX-527 is a cell-permeable, selective inhibitor of SIRT1 (IC50 = 98 nM in vivo, 38nM in vitro) that does not…

P005-5MG 5-mg - $90.00
P005-25MG 25-mg - $320.00

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FK-866 HCl

FK-866 is a selective inhibitor of the nicotinamide pathway dependent NAD+ synthesis, causing NAD+ depletion. Highly specific, non-competitive inhibitor of…

P006-5MG 5-mg - $145.00
P006-25MG 25-mg - $450.00

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Garcinol

Garcinol is an inhibitor of the histone acetyltransferases (HATs) p300 and PCAF with IC50 of 7 and 5 uM, respectively….

P017-5MG 5-mg - $60.00
P017-25MG 25-mg - $220.00

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H-151

H-151 (941987-60-6) is a potent, irreversible inhibitor of Stimulator of Interferon Genes (STING) in mouse and human cells.

P023-10MG 10-mg - $119.00
P023-50MG 50-mg - $449.00

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Hexyl-4-pentynoic acid (HPA)

HPA causes histone hyperacetylation and protect against glutamate induced excitotoxicity in cultured neurons. HPA is one of the most effective…

P008-10MG 10-mg - $60.00
P008-50MG 50-mg - $240.00

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IBMX

IBMX is a widely-used non-specific inhibitor of cyclic AMP and cyclic GMP phosphodiesterases (PDEs) with IC50s from 7 to 50…

P019-100MG 100-mg - $40.00
P019-1GM 1-gm - $180.00

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IOX1

Inhibits the JMJD family of 2-oxoglutarate-dependent histone demethylases. IC50 = 0.12, 0.07, 0.2, 0.3, 0.6, and 1 μM for JMJD3,…

P022-5MG 5-mg - $120.00
P022-25MG 25-mg - $475.00