Specifications

  • Use Stress Marker in as Little as 1 μL Serum or Plasma
  • Sample Serum, Plasma, Saliva, Urine, Respiratory Vapor, and Hair and Fecal Extracts
  • Validation Rodent, Primates, Ungulates, Fish, Whale, Canine
  • Sensitivity 27.6 pg/mL
  • Time to Answer 1.5 Hours
  • Calibrated N-Cal Kit, NIST-Calibrated
  • Samples/Kit 39 or 231 in Duplicate
  • Stability Stable 4°C Liquid Reagents
  • Readout Colorimetric, 450 nm
  • Standard Curve
  • Description

    Cortisol (hydrocortisone, Kendall’s Compound ‘F’) is the primary glucocorticoid produced and secreted by the adrenal cortex. It is often referred to as the “stress hormone” as it affects blood pressure, blood sugar levels, and other actions of stress adaptation. Immunologically, cortisol functions as an important anti-inflammatory and plays a role in hypersensitivity, immunosuppression, and disease resistance. In the metabolic aspect, cortisol promotes gluconeogenesis, liver glycogen deposition, and the reduction of glucose utilization. Production of cortisol follows an ACTH-dependent circadian rhythm, with a peak level in the morning and decreasing levels throughout the day. All but 4% of serum cortisol is bound to proteins including corticosteroid binding globulin and serum albumin. Abnormal cortisol levels are being evaluated for correlation with a variety of different conditions, such as prostate cancer, depression, schizophrenia, Cushing’s Syndrome, and Addison’s Disease.