Chemiluminescent assays (CLIAs) are usually more sensitive than colorimetric assays (EIAs / ELISAs) for the same marker. For example, the Cyclic AMP Direct ELISA Assay (K019-H1/H5) has a sensitivity of 5 fmol, while the Cyclic AMP Direct CLIA Assay (K019-C1/C5) is sensitive to 1 fmol. CLIA assays require a plate reader capable of measuring glow luminescence from the assay, different from the colorimetric readout of optical density.

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