News

Binge Drinking and Future Progeny

It is well documented that alcohol during pregnancy can cause complications for pregnancy and birth, but little is known about the effects of parental binge ethanol (EtOH) drinking on future pregnancy and offspring.

A previous study by Asimes et al, 2017 showed that parental binge EtOH drinking caused modifications to the DNA of their progeny; however, the phenotypical and hormonal alterations in the offspring born to binge EtOH-exposed parents were not explored at that time.… » Read More

Recent Publications Using Our Products

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Aldosterone EIA Kit, K052-H

Corticosterone EIA Kit, K014-H

Cortisol EIA Kit, K003-H –

Cyclic AMP Direct EIA Kit, K019-H –

Glutathione Fluorescent Detection Kit, K006-H –

Oxytocin EIA Kit, K048-H –

PGE2 Multi-Format EIA Kit

  • “4-methoxycinnamyl p-coumarate isolated from Etlingera pavieana rhizomes inhibits inflammatory response via suppression of NF-κB, Akt and AP-1 signaling in LPS-stimulated RAW 264.7 macrophages” (17 Sept 2018) https://doi.org/10.1016/j.phymed.2018.09.193

Urea Nitrogen (BUN) Colorimetric Detection Kit, K024-H – 

» Read More

A Large quantity of Glutathione is Necessary for Hippocampal Neurons to Maintain Healthy Dendrites and Cognitive Function

Post-mitotic neuronal cells are more sensitive to the concentration of reactive oxygen species (ROS) in their surroundings than other cells. To remove excess amounts of deleterious ROS, neurons rely on oxidative phosphorylation and antioxidants such as glutathione (GSH). Previous studies have observed reduced levels of GSH in neuronal cells during neurological disorders, cognitive impairments and aging.… » Read More

Cyclic GAMP EIA Kit

NOW AVAILABLE

World’s First 2′,3′ Cyclic GAMP Direct EIA Kit from
Experts in Cyclic Nucleotide Assays


2′,3′ Cyclic GAMP Direct EIA Kits, Catalog No:  K067-H1/H5

FEATURES

  • Use: Measure cGAMP in STING signaling
  • Range: 50 pmol/mL – 0.205 pmol/mL
  • Time to Answer: 2.5 hours
  • Samples/Kit: 39 or 231 in duplicate
  • Stability: Liquid 4°C Stable Reagents

The innate immune system is the body’s crucial first defense against viral infections and it is dependent upon a group of pattern recognition receptors.… » Read More

Validation of 8 Assays in 8 Species of Whales

Even with significant protections in place, whale populations continue to be low relative to apparent historic norms.   Unfortunately, the reasons for low population and slow population growth have proven to be elusive.  Wild whales are difficult subjects for study.  Samples are hard to obtain, collection stressful for the whales, and getting repeated samples from the same individual over time is extremely rare.  … » Read More

Natal Dispersal is Key To Reproductive Development in Owl Monkeys

Monogamous primates living in small family groups often exhibit delayed patterns of reproduction.   In many species, females will not conceive until after they have left the family group into which they were born and become established within a new group.   There are a number of theories as to why this may happen, and through what means reproduction is suppressed. … » Read More

Fecal Corticosterone Assessment in Socially Housed Lab Animals

A great deal of attention is paid to glucocorticoid levels in connection with the conservation of animal species in the wild or in captivity.  However, monitoring the stress levels of laboratory test animals such as mice and rats can also be critical to understanding the results of the experiments in which they are used. … » Read More

20-Hydroxyecdysone EIA Kit

New Kit Coming in May of 2018!

FEATURES:

Use: Measure 20-hydroxyecdysone from a variety of species
Broad Range: 25,000 pg/mL – 100 pg/mL
Time to Answer: 2.5 hours
Specificity: Highly Specific to 20-hydroxyecdysone, very low cross reactivity with other steroids
Ecdysones are a group of steroid hormones that regulate metamorphosis, cell death, and reproduction in arthropods.… » Read More

The World’s First Cyclic GAMP EIA Kit for STING Signaling Research

Arbor Assays is Pleased to Announce the World’s First Cyclic GAMP EIA Kit for
STING Signaling Research.
Coming in May 2018.

Cyclic GAMP EIA Kit, Catalog No:  K067-H

FEATURES

  • Use: Measure cGAMP in STING signaling
  • Range: 50 pmol/mL – 0.205 pmol/mL
  • Time to Answer: 2.5 hours
  • Samples/Kit: 39 or 231 in duplicate
  • Stability: Liquid, 4°C Stable Reagents

The innate immune system is the body’s crucial first defense against viral infections and it is dependent upon a group of pattern recognition receptors.  … » Read More

Sleep Disruption and Glucose Tolerance

Sleep disturbances, including sleep fragmentation, are known to occur more frequently in individuals with type 2 diabetes than in the general population.   Poor sleep has been shown to negatively impact glycemic control and may exacerbate negative metabolic outcomes when combined with other risk factors.… » Read More

The Use of Normalization Assays

The normalization of specific quantitative assay results is critical to interpretation of biological system status. With cells grown in culture and lysed, a simple total protein determination such as the Bradford assay developed by Marion Bradford at the University of Georgia in 1976 will give an estimate of cellular protein.… » Read More

Role of Rcan1 in Vascular Contractility and Hypertension

Interaction between the serine/threonine protein phosphatase calcineurin and the NFAT family of transcription factors plays a critical regulatory role in the regulation of a variety of physiological functions.   Calcineurin inhibitors are widely used as drugs to suppress inflammation and immune response, including protecting organ transplant recipients from rejection. … » Read More

In Honor of a Dream

“If we are to have peace on earth, our loyalties must become ecumenical rather than sectional. Our loyalties must transcend our race, our tribe, our class, and our nation; and this means we must develop a world perspective.”

Martin Luther King Jr., Christmas 1967

 

April 4th 2018, marks the 50th anniversary of the assassination of Dr.» Read More

Oxidative Stress and Tuberculosis

Tuberculosis (TB) remains one of the leading causes of morbidity and mortality worldwide, while response to the only available vaccine (BCG) varies widely with a number of factors.  In the majority of cases, TB infection in otherwise healthy individuals is rendered latent by the formation for granulomas. … » Read More

Arg8 Vasopressin – Most Sensitive AVP Kit Available

  • MULTI-SPECIES: Mammalian, bird, fish
  • SENSITIVITY: >3 times the sensitivity of any other kit
  • SIMPLE: No C18 column purifications
  • INEXPENSIVE: Extraction solution included
  • SAMPLES/KIT: 38 or 230 in duplicate
  • STABLE: 4°C Stability

The neuropeptides oxytocin and vasopressin were isolated and synthesized by Vincent du Vigneaud at Cornell Medical College in 1953, work for which he received the Nobel Prize in Chemistry in 1955.… » Read More

Oxidative Stress After Hypoxia

Under normal cellular conditions there is a constant balancing act between the creation of reactive oxygen species (ROS) and their elimination by the antioxidant system including enzymes such as superoxide dismutase, glutathione peroxidase, and catalase.  Abnormally low levels of ROS can impede cellular signaling and some normal intracellular reactions, while overly high levels of ROS create oxidative stress which can lead to the improper oxidation of lipids, proteins and DNA resulting eventually resulting in apoptosis, necrosis, and other cellular damage.… » Read More

DetectX Testosterone EIA Kit

Assay Features:

  • Use:                          Non-Invasive Androgen Determination
  • Sample:                    Dried Fecal Extracts Urine, Extracted Serum/Plasma, TCM
  • Species:                   Species Independent
  • Time to Answer:       2.5 Hours
  • Samples/Kit:             39 or 231 in Duplicate

Testosterone, C19H28O2, (4-Androsten-17ß-ol-3-one) is a steroid hormone from the androgen group and is found in mammals, reptiles, birds, and other vertebrates.… » Read More

Immune-Mediated Arthritis and the HPA Axis

 

Acute inflammation is commonly associated with activation of the HPA axis leading to higher levels of circulating glucocorticoids.  However, studies have indicated that some persistent inflammatory conditions, including rheumatoid arthritis, are associated with abnormal HPA responses. What causes this abnormal HPA axis response is not currently understood.  … » Read More

Oxytocin Influences Fear Contagion

Empathy is perhaps the most human of all human traits, but relatively little is understood about how empathy works on a biochemical and neurological level.   In a recent paper by Pisansky et al. the authors examine the phenomenon of fear-contagion, an empathy-like response in mice, and whether oxytocin might play a role in how animals react to the stress of others.… » Read More

Understanding the Impact of Mining on Wildlife

Mining is an inherently invasive and destructive activity with broad ranging and long term effects on the environment.  Despite advances in regulation and oversight, pollution remains a significant and long term problem.

A recent paper by Beyer et al. examined the effects of environmental heavy metal contamination from mine tailing and run off on the white-footed mouse (Peromyscus leucopus).  … » Read More

DHEA-S Measurements Made Simple

Dehydroepiandrosterone (DHEA) is the most abundant circulating C19 steroid in humans. Although DHEA itself has very low androgenic activity, it is the major intermediate in the biosynthesis of the more potent androgen and estrogen sex steroids. DHEA is secreted primarily by the adrenal glands, but may also be produced in the gonads and brain.… » Read More

MPO (Human) EIA Kit

Myeloperoxidase (MPO) is a tetrameric heme-containing protein abundantly produced in neutrophil granulocytes where it plays an important anti-microbial role.  Normally stored in azurophilic granules, MPO is released into the extracellular space during degranulation. There, as part of the neutrophils “respiratory burst” it produces hypochlorous acid from hydrogen peroxide and Cl.… » Read More

Validation of Water-Borne steroid Hormones

As human population grows, our species continues to expand into habitats previously occupied by other species around the globe.  Unfortunately, we do not make very good neighbors.  The impact of human industry and occupation are diverse and devastating.  In addition to the obvious physical habitat lost to concrete and paving, there is further harm done by chemical, noise and light pollution, introduction of non-native species, and increased spread of diseases.  … » Read More

Ceruloplasmin Activity in Urine and Serum

 

Ceruloplasmin (Cp) is a blue-colored glycoprotein that contains six copper ions per molecule. It is an acute phase protein – concentrations increase in response to inflammation – and also functions as the main copper transport system in the body. Copper is incorporated into the molecule when it is synthesized by heptaocytes, and released when the Cp is catabolized.… » Read More

Confusing P450 Data? Simply Measure Formaldehyde

The cytochrome P450 (CYP) superfamily of heme-containing enzymes displays great diversity with regard to substrate specificity and catalytic activity. P450s use a plethora of both exogenous and endogenous compounds as substrates in enzymatic reactions, often functioning as the terminal oxidase enzymes in electron transfer reactions (see figure below).… » Read More

Aldosterone: Regulating Blood Pressure

Aldosterone is a steroid hormone primarily involved in the regulation of sodium and potassium levels in blood as part of the renin-angiotensin system (RAS). Aldosterone increases reabsorbation of sodium from the tubular epithelial cells of kidneys back into the blood, while at the same time moving potassium ions from the blood into the kidneys for eventual excretion in urine.… » Read More

Estrous Cycles in the Somali Wild Ass

Much of what is currently known about the reproductive physiology of wild equine species is based on behavioral observation or data collected from culled individuals.  It is tempting to fill in gaps in knowledge of a rare species by assuming similarity to a more common relative we know more about, however this can be misleading as even closely related species may not exhibit similar reproductive patterns.  … » Read More

Dopamine D1 Receptor Signaling for Steroidogenic Differentiation

Induced pluripotent stem cells are a powerful tool for investigating the molecular mechanisms that underlie cell development in vitro.  A November 2017 paper by Matsuo et al. examined the process of steroidogenic differentiation using human stem cell derived intermediate mesoderm cells known to be the origin of human adrenal cortex and gonads. … » Read More

Cholinesterases: Neurotransmitter Control Systems

The cholinesterase family of enzymes hold important roles in a variety of bodily functions. Acetylcholine esterase (Acetylcholinesterase, AChE) is critical for CNS functions, whereas butyrylcholine esterase (Butyrylcholinesterase, BChE) is a nonspecific cholinesterase enzyme that hydrolyzes many different choline-based esters.

The use of AChE inhibitors as therapeutic agents and pesticides has spurred detailed investigations of cholinesterases after the initial physical characterization of the enzyme by Leuzinger in the late 1960’s (2).… » Read More

Reptile Conservation Across the Globe

The majority of conservation efforts across the globe are based on the well-studied distribution of mammal, bird, and amphibian species, forming much of what we currently understand about global biodiversity.   However, a recent paper in Nature Ecology and Evolution by U.» Read More

Unique Kit for Detecting DNA Damage

Free radicals and other reactive species are constantly generated in vivo and cause oxidative damage to biomolecules. This process is held in check by the existence of multiple antioxidant and repair systems, as well as the replacement of damaged nucleic acids, proteins and lipids.… » Read More

Product Spotlight – Methylation and Demethylation

Methylation and demethylation of cellular proteins and DNA/RNA plays a significant role in the regulation of a variety of signal transduction pathways including protein translation and complex energy transfer systems

Because the enzymes responsible for methylation and demethylation reactions are deeply intertwined with the systems they regulate, these enzymes can be especially tricky to study and understand.  … » Read More

Understanding Reproductive Cycling in Owl Monkeys

Monogamous primates living in small family groups often exhibit delayed patterns of reproduction.   In many species, females will not conceive until after they have left the family group into which they were born and become established within a new group.   There are a number of theories as to why this may happen, and through what means reproduction is suppressed. … » Read More

Research the Cure

Because we believe in giving back to our community, Arbor Assays makes a charitable donation each year based upon the number of kit products sold within that year.  In a program we call “Research the Cure™”, this donation goes directly to a charity supporting medical research chosen by the Arbor Assays employees.  … » Read More

Validation of 8 Assays in 8 Species

Even with significant protections in place, whale populations continue to be low relative to apparent historic norms.   Unfortunately, the reasons for low population and slow population growth have proven to be elusive.  Wild whales are difficult subjects for study.  Samples are hard to obtain, collection stressful for the whales, and getting repeated samples from the same individual over time is extremely rare.  … » Read More

Measure Hemoglobin in 30 Minutes

Hemoglobin is an iron containing, multi-subunit protein responsible for transporting oxygen from the respiratory organs to the rest of the body tissues in vertebrates (with the exception of fish from the family Channichthyidae – which use a different oxygen transport system).… » Read More

Earthworms: An Environmental Indicator Species

Use of nanoparticles in a wide range of consumer and industrial applications is already widespread and expected to increase exponentially during the next decade.   While the properties of the corresponding bulk materials may be familiar and well understood, nanoparticles have unique physiochemical properties and little is currently understood about their long term impact on health and the environment. … » Read More

Environmental Endocrine Disruption

Human beings have been altering our environment since prehistoric times and these changes impact human health and development in many different ways. In modern times, the levels of chemical environmental contaminates that the average human is exposed to have been increasing at an incredible rate with significant impact on health.… » Read More

Cell Signaling

The ability of cells to perceive and correctly adapt to their microenvironment is critical for maintaining normal homeostasis and development as well as for appropriate response to external stimuli. Receptors on the cell surface bind extracellular signaling molecules and transfer that signal to the interior of the cell, setting in motion a cascade of enzymatic reactions and secondary messenger molecules, ultimately altering cell function in response to the extracellular message.… » Read More

Effects of Oxidative Stress on Germination

As seeds age, their ability to germinate declines even if stored under optimal conditions. This loss of production potential is an obstacle to agricultural production and to germplasm and species conservation.  Understanding how this occurs and potentially preventing or slowing the loss of seed vigour is of great interest to plant researchers.… » Read More

Responses of Shelter Dogs to Human Interaction

Domestic dogs are highly social pack animals with an advanced ability to form complex relationships and to read and interpret human behavior, innately so from the first trial with little to no learning curve regardless of age or rearing.  They display a strong attachment for their owners and other familiar people that studies have shown to be analogous to human attachment behaviors.… » Read More

New Retinol Binding Protein (RBP) Multi-Format EIA Kit

Features

  • Two format options in one kit
  • Fast: Results in 90 minutes
  • Stable: Liquid reagents stable at 4°C
  • Economical: 38 or 230 samples in duplicate
  • Validated sample types: Serum, Plasma, Urine and Dried Blood Spots

 

The World Health Organization has estimated 250 million children have moderate to severe Vitamin A deficiency (VAD) due to lack of adequate nutrition and the rising cost of food staples around the world further exacerbates this problem.… » Read More

Measure Stress in Mice with as little as 1 µL of Serum

 

  • As Little as 1 μL Serum or Plasma Sample Required for Duplicate Measurements
  • Proven Results  – Over 200 Literature Citations for EIA and CLIA
  • No extractions necessary
  • Extended Range – 10,000 to 78 pg/ml (EIA) or 3000 to 12.3 pg/ml (CLIA)
  • Results in 90 minutes (EIA) or 2 hours (CLIA)
  • Multispecies – Validated in mice, rats, monkeys, other mammals, birds, reptiles, amphibians
  • High quality, Reliable and Economical
  • Superior stability at 4˚C

Corticosterone is a glucocorticoid secreted by the cortex of the adrenal gland in response to stimulation by adrenocortocotropic hormone.… » Read More

Palladium Detection for API Purification

Features:

  • 30 Minute Assay
  • HTS Compatible 96 Well Plate Format
  • Works with APIs in HCl. NMP, MeCN, DMF, Ethanol, and Toluene
  • Sensitivity 0.082 nM
  • Detection with any Fluorescent Plate Reader

Many new synthetic transformations have been developed that use palladium (Pd) compounds for the catalysis of carbon-carbon and carbon-heteroatom coupling reactions such as the Buchwald-Hartwig, Heck, Kumada, Negishi, Nozaki-Hiyama, Sonogashira, Stille, SuzukiMiyaura, and Tsuji-Trost transformations.… » Read More

Cortisol: Extended Assay Range

 

Now Measure Cortisol from 50 pg/mL – 3200 pg/mL

Cortisol, (hydrocortisone, compound F) is the primary glucocorticoid produced and secreted by the adrenal cortex in humans and other primates. It is often referred to as the “stress hormone” as it is involved in the response to stress, and affects blood pressure, blood sugar levels, and other actions of stress adaptation.… » Read More

Climate Stress and the American Pika

Rapid environmental change, including global warming, presents significant challenges in adaptation for all residents of a changing biome.  The ability to adapt to these challenges, to cope with the environmental stresses created by them, is a key factor in determining what species are likely to survive and which might be pushed to extinction.… » Read More

Suppressing Neutrophils in Inflammatory Response

Over activated or over abundant neutrophils generate superoxide anion and other reactive oxidants which can create significant oxidative stress and may play a key role in the progression and development of both acute and chronic inflammatory disease.   Understanding and eventually blocking the burst of neutrophil activity associated with some inflammatory diseases holds promise as a treatment modality for a number of diseases that are currently poorly managed for patients. … » Read More

Measuring Cortisol in Hair Samples

Studies in a wide range of species1-5,7 have shown that the stress hormone cortisol can be measured in hair samples.  Furthermore, since it has been proven cortisol is deposited in hair as the hair grows, hair cortisol levels can provide information on chronic or long term stress levels that may not be observable in the relative snap-shot provided by fecal or blood samples.  … » Read More

Oxidative Stress as a Result of Acute Hypoxia

Under normal cellular conditions there is a constant balancing act between the creation of reactive oxygen species (ROS) and their elimination by the antioxidant system including enzymes such as superoxide dismutase, glutathione peroxidase, and catalase.  Abnormally low levels of ROS can impede cellular signaling and some normal intracellular reactions, while overly high levels of ROS create oxidative stress which can lead to the improper oxidation of lipids, proteins and DNA resulting eventually resulting in apoptosis, necrosis, and other cellular damage.… » Read More

The Effects of LNG Contamination on Aquatic Life

When considering the impact of chemicals our planet and the life forms that live here, it is instinctive to focus on things like highly toxic or carcinogenic solvents or other industrial materials. These sorts of toxins certainly are harmful to the environment and appropriate containment and disposal is a must, however there is another group of chemicals that pose significant but much less understood risk – prescription and over the counter drugs. … » Read More

Influence of Rearing on Captive Tigers

Animal welfare has been defined as “a state of complete health, both physical and mental, in which the animal is in harmony with its environment.   Welfare assessment is an important component in the care of all zoo animals, but is even more critical for individuals who were hand-reared because their reactions to various potential environmental stressors may be different from those of animals reared by a parent. … » Read More

Oxidative Cost of Reproduction

 

The physical “costs” of reproduction to an organism, particularly under less than ideal conditions, have been the subject of many studies in recent years.  Theories suggest the physical investment in a pregnancy may sometimes come at the cost of either individual survival or future reproductive events.  … » Read More

Fecal Glucocorticoid Measurements to Monitor Situational Stress

 

Thanks to many years of careful planning and habitat restoration, several species including Black footed ferrets, California condors, Grey wolves, Musk ox, Golden eagles and Northern river otters have been or are being reintroduced into areas of their range where historic populations have disappeared or greatly diminished due to pressure from various human activities.  … » Read More

Cystatin C as a Marker for Renal function

Glomular Filtration Rate (GFR) is the metric normally used to assess kidney function. It can be determined either by measuring the concentration of endogenous markers such as urea nitrogen or creatinine in serum, or by measuring the clearance rate of exogenous indicators such as inulin, iohexol or 51Cr-EDTA or 125I-iothalamate.… » Read More

Time of Day Influences Inflammatory Response to Cytotoxic Chemotherapy

 

 

It has been demonstrated cancer chemotherapy depends on administration of treatment at times that coincide with both optimal drug metabolism and cellular processes such as apoptosis, DNA repair and changes to cell cycle progression. Given we know immune response is also strongly influenced by circadian cycles, it seems reasonable to consider the possibility that the daily cycles of cytokines and immune response proteins may also contribute to the effectiveness of chemotherapeutics. … » Read More

Monitoring Reproductive Status in Bird Feces

Monitoring of reproductive endocrinology is a very important tool in the management of animal populations both in captivity and in the wild.   Whenever possible measuring key indicators such as estrogens, progestogens, and androgens using non-invasive sample types is prefered so that animals under study are not subjected to the stress of handling and blood collection.… » Read More

Adapting to Climate Change

 

Stress and mineralization responses to environmental stress in Mantis Shrimp

Calcified marine organisms face a double edged sword as global warming increases not only the temperature of ocean waters, but also the level of acidification.  Many such organisms that live within the intertidal zone are already adapted to cope with the broad fluctuations in temperature and pH that occur with each tidal cycle – but precisely how the species cope with the stressors of increased temperature and decreased pH varies widely and have costs that can include increased energy demands, growth restriction, physiological stress, and changes in mineralization. … » Read More

The Role of Thyroxine in Photo Stimulation

Changes in the length of day throughout the year can be a marker for critical species functions such as migration, hibernation, and mating.  These changes have been shown to affect an organism’s morphology and hormones as well as other biomarkers. For example, the thyroid hormones T3 and T4 have previously been demonstrated to have roles in the regulation of photoperiod response in birds.  … » Read More

New! – Allopregnanolone EIA Kit, Monoclonal Antibody Based

Allopregnanolone is made from progesterone which is converted into 5α-dihydroprogesterone by 5α-reductase type I, and 3α-hydroxysteroid oxidoreductase isoenzymes. This 5α-dihydro intermediate is then converted into allopregnanolone. 3α-hydroxysteroids do not interact with classical intracellular steroid receptors but bind stereoselectively and with high affinity to receptors for the major inhibitory neurotransmitter in brain, γ-amino-butyric acid (GABA). … » Read More

Human Myeloperoxidase EIA kit

 

Myeloperoxidase (MPO) is a tetrameric heme-containing protein abundantly produced in neutrophil granulocytes where it plays an important anti-microbial role.  Normally stored in azurophilic granules, MPO is released into the extracellular space during degranulation. There, as part of the neutrophils “respiratory burst” it produces hypochlorous acid from hydrogen peroxide and Cl.… » Read More

Corticosterone: Ruling out stress

The measurement of stress hormones such as corticosterone or cortisol is generally associated with research focused on impacts of stress or stress management. However, there are many times when it may be just as important to rule out stress as a potential cause for neurological symptoms or behaviors.… » Read More

Cortisol: A measurable link between behaviors and stress

Stress – the condition keepers and animal husbandry professionals most want to avoid for the animals in their care. Psychosocial and environmental stress can have significant effects not just on day to day mood and demeanor, but also on the immune system, reproduction, and life span.… » Read More

FRAP – Measuring antioxidant potential

Oxidative stress has been implicated in a wide variety of pathologies including Parkinson’s disease, Alzheimer’s disease, atherosclerosis, heart attack and cardiovascular disease, cancer, diabetes, and chronic fatigue syndrome. Oxidative stress also triggers a process called mitohormesis, which may play a significant role in normal aging.… » Read More

Simplify your Glutathione Measurements

Glutathione (GSH) is a tripeptide (gamma-L-glutamyl-L-cysteinylglycine) that is found in all mammalian tissues and is especially concentrated in the liver (1-10 mM).  Along with its known function combating oxidative stress, GSH is also important for the detoxification of xenobiotics and metabolites, the regulation of cell growth and cell death, the regulation of the nitric oxide cycle, the storage of cysteine, the maintenance of redox potential and the modulation of immune function.… » Read More

Practical Biology: Getting the Most out of the Samples You Have

An important consideration in the study of hormones is their variability in response to internal and external stimuli, which can provide insight into a variety of biological processes of interest to conservation and management. This essential variability is, of course, what makes these molecules valuable to study, but it adds interesting complications to the sample collection.… » Read More

Thyroxine EIA – Ideal for Metabolomics

  • ≤ 5 μL Serum or Plasma Sample: for duplicate measurements
  • No Extractions Needed
  • Validated for Multiple Sample Types: Plasma, Serum, Urine, Fecal Extracts, Media and Dialysates
  • High Quality and Economical
  • All with superior 4°C Liquid Stability

Metabolomics involves the characterization of small molecule metabolites found in an organism, increasingly used in health applications such as pharmacology, pre-clinical drug trials, toxicology, transplant monitoring, newborn screening and clinical chemistry.… » Read More

DHEA-S Measurements Made Simple

Dehydroepiandrosterone (DHEA) is the most abundant circulating C19 steroid in humans. Although DHEA itself has very low androgenic activity, it is the major intermediate in the biosynthesis of the more potent androgen and estrogen sex steroids. DHEA is secreted primarily by the adrenal glands, but may also be produced in the gonads and brain.… » Read More

Non-Invasive Pregnancy Analysis

17-Hydroxyprogesterone (17-HO-P) is a steroid hormone from the androgen group found in mammals, reptiles, birds, and other vertebrates. It was first isolated from the adrenal glands of cattle by Pfiffner and North at Parke, Davis and Company in Detroit, Michigan in 19401.… » Read More

Sensitive Assays for Cyclic Nucleotide Signaling

Cyclic adenosine monophosphate (cyclic AMP or cAMP) and cyclic guanosine monophosphate (cyclic GMP or cGMP) are prolific intracellular signaling molecules. cAMP is synthesized from adenosine triphosphate (ATP) by the enzyme adenylyl cyclase (AC) and used for intracellular signal transduction in many different organisms.… » Read More

Measure Stress in Mice with 1 µL of Plasma or Serum

Glucocorticoids like corticosterone guide fundamental processes associated with converting sugar, fat, and protein stores to useable energy, inhibiting swelling and inflammation, and suppressing immune responses following a stress event. Corticosterone is a glucocorticoid secreted by the cortex of the adrenal gland in response to stimulation by the adrenocorticotropic hormone.… » Read More

Cortisol Plays Role in Poor Stress Recovery in Depression

Researchers examining developmental antecedents of depression in adolescents looked at the relationship between cognitive vulnerabilities and poor recovery of the biological stress system as measured through heart rate and cortisol. In their study published in February 2016, authors found a strong link between higher depressive symptoms and the combination of greater cognitive vulnerabilities and lower cortisol and heart rate recovery.… » Read More

Our PGE2 EIA Kit Measures PGE2 Concentrations in Any Sample

The Arbor Assays Prostaglandin E2 (PGE2) Multi-Format EIA Kit uses a unique Prostaglandin E2 monoclonal antibody developed by Arbor Assays that allows one assay to handle all the formats and sensitivities previously covered by the hugely popular and well-published K018 series of PGE2 immunoassays (EIA, CLIA and High-Sensitivity EIA), which it replaces.… » Read More

Catalase, an Indicator of Environmental Stress

As climate change and the human population continues to increase, understanding the impact these changes have on our world and the species it harbors becomes ever more critical. Experimental understanding of the stress responses of key animal species can provide a means of quantitatively measuring the biological impact of factors like temperature change, xenobiotic contamination, crowding, and resource loss individually or in combinations that mimic projected real world conditions.… » Read More

Oxytocin: The “Love Hormone”

The neuropeptides oxytocin and vasopressin were isolated and synthesized by Vincent du Vigneaud at Cornell Medical College in 1953, work for which he received the Nobel Prize in Chemistry in 1955. Oxytocin is highly conserved across vertebrate species and consists of nine amino acids linked with a [1-6] disulfide bond and a semi-flexible carboxyamidated tail.… » Read More

NEW Levonorgestrel (LNG) Kit

Levonorgestrel (LNG) is a synthetic steroid analogue used in a number of birth control methods. Levonorgestrel was first made in the 1960s and has been used as a method of birth control since the 1980s. Today it is on the World Health Organization’s List of Essential Medicines, the most important medications needed in a basic health system, and is available as a generic medication.… » Read More

Arg8-Vasopressin Assay: Most Sensitive

The neuropeptides oxytocin and vasopressin were isolated and synthesized by Vincent du Vigneaud at Cornell Medical College in 1953, work for which he received the Nobel Prize in Chemistry in 1955. The neurohypophysial hormone arginine vasopressin (AVP), also known as antidiuretic hormone, is involved in a wide range of physiological regulatory processes, including renal water reabsorption, cardiovascular homeostasis, hormone secretion from the anterior pituitary, and modulation of social behavior and emotional status.… » Read More

The Use of Normalization Assays

The normalization of specific quantitative assay results is critical to interpretation of biological system status. With cells grown in culture and lysed, a simple total protein determination such as the Bradford assay developed by Marion Bradford at the University of Georgia in 1976 will give an estimate of cellular protein.… » Read More

Endothelin-1: Potent Vasoconstrictor

Endothelin-1 (ET-1), a peptide of 21 amino acid residues, is a pleiotropic molecule known for its action as a potent vasoconstrictor. ET-1 is one of a family of three proteins encoded by distinct genes that also includes Endothelin-2 (ET-2) and Endothelin-3 (ET-3).… » Read More

ThioStar®: A Better Way to Measure Free SH Groups

  • SENSITIVE: Measure < 500 fmol Free Thiol
  • RAPID: Bright Fluorescence in Seconds
  • SOLUTION STABILITY: 2 Months at 4°C
  • LARGE STOKES SHIFT: Excite at 390 nm, Read at 510 nm
  • LOW BACKGROUND: Almost No Signal from Unreacted ThioStar®
  • VERSATILE: Soluble in Common Solvents and Water
  • FLEXIBLE FORMAT: Microplates, Cuvettes or HPLC

Simple, Stable and Sensitive

The ThioStar® molecule is designed to quantitatively measure thiol groups generated or present in samples.… » Read More

Ann Arbor SPARK Honors Arbor Assays with FastTrack Award

NOVEMBER 16, 2015 – Ann Arbor SPARK recently presented its annual FastTrack award to Arbor Assays for its impressive record of growth, along with 13 other Washtenaw County-based companies.

FastTrack awards are presented to companies with a 2011 revenue of at least $100,000 and an annual growth of 20 percent during the subsequent three years, which Arbor Assays exceeded.… » Read More

Arbor Assays becomes ISWE Official Supplier

Arbor Assays and the International Society of Wildlife Endocrinology (ISWE) signed an exclusive agreement for Arbor Assays to supply ISWE members with EIA kits for wildlife conservation research.  The Agreement was signed this October at SEZARC, the South-East Zoo Alliance for Reproduction & Conservation in Yulee, Florida.… » Read More

BEST Internship Program Participation

The BEST Internship Pilot is a program offered by the NIH to doctoral students seeking internships in six career areas- law, business, communication, teaching, community engagement, and government. Broadening Experiences in Scientific Training (BEST) was designed for doctoral students interested in exploring careers beyond academia.… » Read More

New Oxytocin CLIA Kit

The DetectX® Oxytocin CLIA assay is the world’s most sensitive assay to measure oxytocin.  Sensitivity of 6.3 pg/mL.  Measures all species.

» Read More

Allopregnanolone EIA Kit Launched

Another unique product.

The DetectX® Allopregnanolone Immunoassay (EIA/ELISA) kit is designed to quantitatively measure Allopregnanolone present in serum, plasma, extracted dried fecal samples, urine and tissue culture media samples.

Read More >>

An allopregnanolone standard is provided to generate a standard curve for the assay and all samples should be read off the standard curve.… » Read More

Expansion Open House


On June 5th, 2013 we hosted an Open House to celebrate our recent expansion and renovation.  We doubled our premises and added improved workspace, workflow, lighting, energy efficiency, and installation of a larger generator.  We hosted 50 local business leaders, bankers, attorneys, web designers, artists and the people who made the expansion possible.… » Read More

Arbor Assays 2013 MS Walk

For the sixth consecutive year as Arbor Assays, we, along with family and friends, have participated in Walk MS on June 22, 2013 to raise awareness and funds to support the National Multiple Sclerosis Society.  The weather was hot, the Hudson Mills Metropark route relaxing and we had a great time!  … » Read More

FRAP™ Assay Introduced

Reactive oxygen species (ROS) are produced as a consequence of normal aerobic metabolism and the free radicals produced may be responsible for a variety of pathological conditions including Parkinson’s and Alzheimer’s diseases, atherosclerosis, myocardial infarction, and chronic fatigue syndrome.

The FRAP™ (Ferric Reducing Ability of Plasma) Assay Kit is designed to quantitatively measure antioxidant status in a variety of samples.… » Read More

New Publications and Newsletter Sign Up Form

Cyclic AMP Chemiluminescent CLIA Kit –

“Autocrine Regulation of Macrophage Activation via Exocytosis of ATP and Activation of P2Y11 Receptor”

Link: http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0059778

Urea Nitrogen (BUN) Detection Kit –

“Associations between endotoxin-induced metabolic changes and temperament in Brahman bulls”

Link: http://onlinelibrary.wiley.com/doi/10.1111/jpn.12074/abstract?deniedAccessCustomisedMessage=&userIsAuthenticated=false

Corticosterone Colorimetric EIA Kit –

“Effect of Breed, Cage Type, and Reproductive Phase on Fecal Corticosterone Levels in Doe Rabbits

Link: http://www.tandfonline.com/doi/abs/10.1080/10888705.2013.768903

Corticosterone Colorimetric EIA Kit –

“Natural variation in circulating testosterone does not predict nestling provisioning rates in the northern cardinal, Cardinalis cardinalis”

Link: http://www.sciencedirect.com/science/article/pii/S000334721300095X

Corticosterone Colorimetric EIA Kit – “Modulation in Wistar Rats of Blood Corticosterone Compartmentation by Sex and a Cafeteria Diet”

Link: http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0057342

GSH Colorimetric Detection Kit –  “Glutathione Supplementation Improves Macrophage Functions in HIV”

Link: http://online.liebertpub.com/doi/abs/10.1089/jir.2012.0103

PGE2 EIA Kit –  “Abnormal circadian rhythm and cortisol excretion in autistic children: a clinical study”

Link:http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3583392/pdf/CroatMedJ_54_0033.pdf

PGE2 EIA Kit –  “Microglia Are Essential to Masculinization of Brain and Behavior”

Link: http://www.jneurosci.org/content/33/7/2761.short

Cyclic AMP Direct EIA Kit –  “Identifying Target Genes related to Respiratory Network Dysfunction in a Mouse Model for the Rett Syndrome”

Link: https://ediss.uni-goettingen.de/bitstream/handle/11858/00-1735-0000-000D-F68F-C/Thesis_Steffen%20Vogelgesang1.pdf?sequence=1

PLUS!  » Read More

New Dual Range BCA Protein Detection Kit Launched

Just add samples!  Our new Total Protein Detection kit gives you everything you need to measure the protein content of serum, urine, lysates or homogenates.  The most sensitive BCA kit available can measure <1.7 ug/mL of protein or about 84 pg of protein!  … » Read More

January 2013 Publications and Newsletter Sign Up Form

Formaldehyde Fluorescent Kit – “GROWTH AND DEVELOPMENT SYMPOSIUM:Development, characterization, and use of a porcine epiblast-derived liver stem cell line: ARS-PICM-19″

Link: http://www.journalofanimalscience.org/content/91/1/66.abstract?sid=be28c1d4-618c-4bb6-986b-a96d19aa72ad

ThioStar® – “Transcription and redox enzyme activities: comparison of equilibrium and disequilibrium levels in the three-spined stickleback”

Link: http://rspb.royalsocietypublishing.org/content/280/1755/20122974.short

ThioStar® – “Resistance to oxidative damage but not immunesuppression by organic tin compounds in natural populations of Daubenton’s bats (Myotis daubentoni)”

Link: http://www.sciencedirect.com/science/article/pii/S1532045613000148

GSH Fluorescent Kit – “Bisphenol A activates Nrf1/2-antioxidant response element pathway in HEK 293 cells”

Link: http://pubs.acs.org/doi/abs/10.1021/tx400036v

PGE2 CLIA – “Ibuprofen Inhibits Colitis-Induced Overexperssion of Tumor-Related Rac1b”

Link: http://www.neoplasia.com/pdf/manuscript/v15i01/neo121890.pdf

cAMP Direct EIA – “Zolmitriptan: A Novel Portal Hypotensive Agent Which Synergizes with Propranolol in Lowering Portal Pressure”

Link: http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0052683

Serum Creatinine Detection – “High Glucose Induced Alteration of SIRTs in Endothelial Cells Causes Rapid Aging in a p300 and FOXO Regulated Pathway”

Link: http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0054514

Cortisol EIA – “Yeast cell wall supplementation alters aspects of the physiological and acute phase responses of crossbred heifers to an endotoxin challenge”

Link: http://ini.sagepub.com/content/early/2013/01/03/1753425912469673.abstract

Glutathione Colorimetric Detection – “Glutathione Supplementation Improves Macrophage Functions in HIV”

Link: http://www.researchgate.net/publication/232609896_Glutathione_and_infection

PLUS!  » Read More

5 New Publications Using Our Kits

Cyclic GMP EIA – “Distant effects of nitric oxide inhalation in lavage-induced lung injury in anaesthetised pigs”

Link: http://www.ncbi.nlm.nih.gov/pubmed/23198970

PGE2 EIA – “Cyclooxygenase-2 Is a Target of MicroRNA-16 in Human Hepatoma Cells”

Link: http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0050935

PGE2 EIA – “Ethanolic Leaf Extract of Croton Zambesicus (MÜll.… » Read More

4 New Publications using our Kits

Urinary Creatinine Paper -“Reversal of the deleterious effects of chronic dietary HFCS-55 intake by PPAR-δ agonism correlates with impaired NLRP3 inflammasome activation?” 

Link: http://www.sciencedirect.com/science/article/pii/S0006295212006909

Serum Creatinine Paper – “Stem Cell Transplantation Increases Antioxidant Effects in Diabetic Mice”

Link: http://www.biolsci.org/v08p1335.htm

Cortisol EIA Paper– “Yeast cell wall supplementation alters the performance and health of newly received crossbred heifers”

Link: http://repositories.tdl.org/ttu-ir/bitstream/handle/2346/46725/YOUNG-THESIS.pdf?sequence=1

Urea Nitrogen (BUN) Paper – “Yeast cell wall supplementation alters the performance and health of newly received crossbred heifers

Link: http://repositories.tdl.org/ttu-ir/bitstream/handle/2346/46725/YOUNG-THESIS.pdf?sequence=1

» Read More

New Corticosterone CLIA Paper on Genetic KCa3.1 Deficiency in Mice

The calmodulin/calcium-activated K+ channel KCa3.1 is expressed in red and white blood cells, epithelia and endothelia, and possibly central and peripheral neurons. The knowledge about its contribution to neurological functions and behavior is incomplete. The paper examines whether genetic deficiency or pharmacological activation of KCa3.1 change behavior and cerebral monoamine levels in mice.… » Read More

New Glucose Fluorescent Detection Kit Launched

Our new Glucose Fluorescent Detection kit, K039-F1, for serum, plasma, urine, cell extract samples has been launched.  The 2 by 96-well plate contains everything needed to measure glucose in < µL amounts of serum and plasma.  All liquid, 4°C stable kit.… » Read More

New cAMP CLIA assay paper published

A paper in PLOS One, entitled “(S)-α-Chlorohydrin Inhibits Protein Tyrosine Phosphorylation through Blocking Cyclic AMP – Protein Kinase A Pathway in Spermatozoa” was published today.  This paper describes the use of our chemiluminescent cAMP assay, K019-C1, in the measurement of cAMP in rat sperm.… » Read More

New Kit Box

We have just received our new kit boxes.  It is a brighter rethink of our original kit box made from a more water resistant card stock. Still completely recyclable.  Look for these in your lab soon.

 

» Read More

ISWE Travel Grant Awarded

Arbor Assays has awarded a €1,000.00 travel grant to Ekaterina Pavlova of the A. N. Severtsov Institute of Ecology and Evolution in Moscow, Russia to help offset costs associated with her presentation at the 3rd ISWE Conference to be held in Vienna, Austria, September 23-26, 2012.  … » Read More

Estrone-3-Sulfate EIA Kits launched

For the non-invasive determination of E1S and metabolites in serum, plasma, urine and fecal samples we have launched our new Estrone-3-Sulfate (E1S) EIA Assay Kits, K038-H1 and K038-H5. Clinical studies have indicated the utility of measuring estrone-3-sulfate (E1S) in samples from male horses to monitor cryptorchidism.… » Read More

Pregnanediol-3-Glucuronide (PDG) EIA kits launched

For the non-invasive determination of PDG and its metabolites in urine and fecal samples, or in extracted serum and plasma we have launched our new Pregnanediol-3-Glucuronide (PDG) EIA Assay Kits, K037-H1 and K037-H5. Clinical studies have indicated the utility of measuring PDG in samples of urine to monitor ovarian function in females

Kit manual:  Pregnanediol-3-Glucuronide (PDG) EIA Assay Kits

» Read More

Human Osteopontin EIA kit Launched

The world’s most sensitive EIA kit for measuring human Osteopontin (OPN) has been launched. This is a double monoclonal antibody based kit where the antibody coated on the plate recognizes only intact hOPN.  The assay which can be used for EDTA plasma, urine, milk and culture media, shows linear response with dilution and will measure down to 250 pg/mL hOPN.… » Read More

Estrone-3-Glucuronide (E1G) EIA Assay kits launched

For the non-invasive determination of E1G and its metabolites in urine and fecal samples, or in extracted serum and plasma we have launched our new Estrone-3-Glucuronide (E1G) EIA Assay Kits, K036-H1 and K036-H5. Clinical studies have indicated the utility of measuring estrone-3-glucuronide (E1G) in samples of urine to monitor ovarian function in females

Kit manual:  Estrone-3-Glucuronide (E1G) EIA Assay Kits

» Read More

Ceruloplasmin Activity kit

For the non-invasive determination of pregnancy in urine samples we have launched our new Ceruloplasmin (Cp) Colorimetric Activity Assay Kit, K035-H1.  This kit has been shown to measure increasing levels of Cp activity which is expressed in elevated amounts during pregnancy.… » Read More

American Society for Cell Biology Exhibit Booth

Visit us at booth # 722 at ASCB, San Diego, December 5-9, 2009
We will have an exhibit booth at the American Society for Cell Biology for the first time. Our booth number is 722 so please stop by and visit us.… » Read More

New Distributor Announcement

Arbor Assays announces new distributor for South East Asia

Arbor Assays announces today that it has signed 3 new distributors in SE Asia. vCell Science is out new distributor in Singapore and Axon Scientific will represent us in Malaysia. We have also signed PT Genetika in Indonesia.… » Read More

New Distributor Announcement

Arbor Assays announces new distributor for Spain and Portugal
Arbor Assays today announced the appointment of exclusive distributor for Spain and Madrid. LabNet Biotécnica S.L. has been appointed as Arbor Assays’ exclusive distributor in Spain and Portugal. Full contact details can be found in our Distributor section.… » Read More

New Distributor Announcement

Arbor Assays announces the addition of 3 new distributors
Arbor Assays today announced the appointment of exclusive distributors for South Africa and Turkey and an additional distributor in China. BIOCOM Biotech has been appointed as Arbor Assays’ exclusive distributor in South Africa.… » Read More

Publication Announcement

May 2009 Edition of Clinical Chemistry, 55:895-903

Two Arbor Assays scientists are co-authors on a paper that has just been published in the May 2009 edition of Clinical Chemistry. The paper is entitled “New Dual Monoclonal ELISA for Measuring Plasma Osteopontin as a Biomarker Associated with Survival in Prostate Cancer: Clinical Validation and Comparison of Multiple ELISAs” by Peter H.… » Read More

January 14, 2009 Press Release

ANN Arbor, Mich. — (BUSINESS WIRE)
February 25, 2009

January 14, 2009: Arbor Assays and University of Michigan Patent New Demethylase Assay Technology

Two scientists at Arbor Assays, LLC and Professor Ray Trievel from the Department of Biological Chemistry at the University of Michigan filed a US patent application that relates to a new, novel method to detect demethylase enzyme activity.… » Read More

Arbor Assays Honored with MS Walk Team Award

Arbor Assays receives Bronze Team Award for the 2008 MS Walk from the Michigan chapter of the MS Society

Arbor Assays LLC has received a Bronze Team Award from the Michigan chapter of the MS Society for its money raising activity.… » Read More

Cortisone

Cortisone was identified by Mason, Myers and Kendall in 1936 as Compound E extracted from bovine suprarenal gland tissue that had the qualitative but not quantitative activity of cortin. The presence of multiple cortin-like compounds led the authors to speculate that the study of Compound E would reveal the nature of cortin.… » Read More

Cystatin C as a Marker of Kidney Function

Glomular Filtration Rate (GFR) is the metric normally used to assess kidney function. It can be determined either by measuring the concentration of endogenous markers such as urea nitrogen or creatinine in serum, or by measuring the clearance rate of exogenous indicators such as inulin, iohexol or 51Cr-EDTA or 125I-iothalamate.… » Read More

Palladium Detection for API

Features:

  • 30 Minute Assay
  • HTS Compatible 96 Well Plate Format
  • Works with APIs in HCl. NMP, MeCN, DMF, Ethanol, and Toluene
  • Sensitivity 0.082 nM
  • Detection with any Fluorescent Plate Reader

Many new synthetic transformations have been developed that use palladium (Pd) compounds for the catalysis of carbon-carbon and carbon-heteroatom coupling reactions such as the Buchwald-Hartwig, Heck, Kumada, Negishi, Nozaki-Hiyama, Sonogashira, Stille, SuzukiMiyaura, and Tsuji-Trost transformations.… » Read More

20-Hydroxyecdysone EIA Kit – New Product

Now Available

20-Hydroxyecdysone EIA Kit, K066-H

FEATURES:

Use: Measure 20-hydroxyecdysone from a variety of species
Broad Range: 25000 pg/mL – 100 pg/mL
Time to Answer: 2.5 hours
Sample Volume: 50 μL
Specificity: Highly Specific to 20-hydroxyecdysone, very low cross reactivity with other steroids
Ecdysones are a group of steroid hormones that regulate metamorphosis, cell death, and reproduction in arthropods.… » Read More

RBP: Tracking Vitamin A Deficiency

The World Health Organization has estimated 250 million children have moderate to severe Vitamin A deficiency (VAD) due to lack of adequate nutrition, and the rising cost of food staples around the world further exacerbates this problem. In addition to nutritional deficiencies, infectious stresses have been shown to depress retinol concentrations causing individuals with diseases that interfere with adsorption or storage of vitamin A such as cystic fibrosis, pancreatic insufficiency, duodenal bypass, celiac, cirrhosis etc.… » Read More

Cranberry Extract Reduces Oxidative Stress Levels

Cranberry juice has long been known to have antioxidant properties attributed to high levels of polyphenols.  While much research has been done concerning the impact of cranberries and cranberry juice on urinary tract infections, fewer studies have examined their effects on other pathologies.  … » Read More

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Arbor Assays will be closed November 22 and 23 for the Thanksgiving Holiday