Aldosterone: Monitoring the Regulation of Blood Pressure
Aldosterone is a steroid hormone that plays a key role in blood pressure regulation and electrolyte balance. Part of the renin-angiotensin-aldosterone system (RAAS), aldosterone signals the kidneys to reabsorb sodium and excrete potassium. This process retains water, increasing blood volume and helping maintain stable blood pressure.
The Impact of Aldosterone on HealthÂ
Elevated aldosterone levels, or hyperaldosteronism, can lead to sodium retention, potassium loss, and increased water retention, all of which raise blood pressure. Chronic high blood pressure (hypertension) significantly increases the risk of cardiovascular events such as heart attacks and strokes, as well as kidney disease and failure. Managing aldosterone levels is essential to preventing these complications and improving long-term health outcomes.
Clinical Applications of Aldosterone RegulationÂ
Pharmaceutical interventions that influence aldosterone secretion or activity are a cornerstone of hypertension treatment. Medications like lisinopril, an ACE inhibitor, reduce aldosterone synthesis by disrupting the RAAS pathway. Others, like spironolactone, act as aldosterone receptor antagonists, directly blocking aldosterone’s effects. These medications help reduce fluid overload, maintain potassium balance, and protect the cardiovascular and renal systems. In patients with resistant hypertension or heart failure, aldosterone-targeting therapies are often part of combination treatment strategies.
Measuring Aldosterone for Health InsightsÂ
Testing for aldosterone helps identify underlying causes of high blood pressure and guides treatment decisions. Blood or urine tests can quantify aldosterone levels, with normal adult blood ranges typically falling between 3.1 and 35.4 ng/dL according to the Cleveland Clinic. An elevated aldosterone-to-renin ratio may indicate primary aldosteronism, a common but underdiagnosed cause of secondary hypertension. Early detection through accurate aldosterone measurement is critical for reducing the risk of cardiorenal disease.
Broader Implications of Aldosterone Beyond Blood PressureÂ
Excess aldosterone is not just linked to high blood pressure. It also contributes to tissue inflammation, fibrosis, and oxidative stress. These effects can accelerate the progression of heart failure, chronic kidney disease, and even diabetic neuropathy. Recent studies suggest that unchecked aldosterone activity may worsen organ function independent of blood pressure levels. This highlights the broader clinical significance of aldosterone regulation.
Tools for Measuring AldosteroneÂ
The DetectX® Aldosterone ELISA (K052-H1/H5) and Chemiluminescent ELISA Kits (K052-C1/C5) from Arbor Assays offer sensitive, accurate detection of aldosterone in extracted serum, plasma, urine, and tissue samples. With run times ranging from 2.5 to 16 hours and easy-to-use liquid reagents stored at 4°C, these kits support both clinical diagnostics and research applications.
Versatility and Precision of Arbor Assays’ KitsÂ
Arbor Assays’ ELISA kits detect aldosterone concentrations as low as 4.97 pg/mL (K052-H) and 2.06 pg/mL (K052-C), ensuring high sensitivity across a variety of sample types. The use of a standard curve in each assay provides reliable, reproducible data, essential for studies involving endocrine disorders, cardiovascular risk, or RAAS-related dysfunction.
Managing Aldosterone for Better Health
Understanding aldosterone’s role in fluid balance, blood pressure, and organ health is essential for clinical and research settings. With DetectX® Aldosterone ELISA Kits, Arbor Assays empowers researchers and clinicians to track this hormone with confidence. Early detection and monitoring of aldosterone imbalances can help prevent hypertension-related complications and support better health outcomes for patients.
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Featured Products
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In StockAldosterone ELISA Kit
$440.00 – $1,756.00The DetectX® Aldosterone ELISA Kits measure Aldosterone present in extracted serum and plasma, or in urine, saliva, extracted dried fecal samples, and tissue culture media samples.
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Limited AvailabilityAldosterone Chemiluminescent ELISA Kit
$460.00 – $1,837.00The DetectX® Aldosterone Chemiluminescent ELISA Kits quantitatively measure Aldosterone present in extracted serum and plasma, or in urine, saliva, extracted dried fecal samples, and tissue culture media samples
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