Chronic repeated unpredictable stress induces PTSD in mice… and likely humans, too.
Chronic stress can lead to dysregulation of hypothalamic-pituitary-adrenal (HPA) axis function, and is implicated in diseases like depression and post-traumatic stress disorder (PTSD). The development of treatments for stress-related disorders requires a better understanding of the biological basis of HPA axis dysfunction. A recent study by Algamal, et al. investigated the neuroendocrine and biochemical assessment of HPA axis function in a mouse model of chronic stress by inducing chronic stress in mice through a program of repeated unpredictable stress (RUS) followed by chronic social isolation.
The effect of RUS on the HPA axis function was measured partly through analysis of glucocorticoid levels using DetectX® Corticosterone and cAMP ELISA kits from Arbor Assays. Stressed mice exhibited disruption in HPA-axis signaling and PTSD behavioral deficits such as exaggerated fear memory recall and anxiety-like behavior even one month after being subjected to RUS. These behaviors are similar to those in humans, suggesting this model is suitable for examining the mechanisms behind fear-related abnormalities in PTSD.
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