News

Chronic Stress & PTSD

Image of gloved hands holding a laboratory mouse

Chronic repeated unpredictable stress induces PTSD in mice… and likely humans, too.

Chronic stress can lead to dysregulation of hypothalamic-pituitary-adrenal (HPA) axis function, and is implicated in diseases like depression and post-traumatic stress disorder (PTSD). The development of treatments for stress-related disorders requires a better understanding of the biological basis of HPA axis dysfunction.  A  recent study by Algamal, et al. investigated the neuroendocrine and biochemical assessment of HPA axis function in a mouse model of chronic stress by inducing chronic stress in mice through a program of repeated unpredictable stress (RUS) followed by chronic social isolation.

The effect of RUS on the HPA axis function was measured partly through analysis of glucocorticoid levels using DetectX®  Corticosterone and cAMP ELISA kits from Arbor Assays.  Stressed mice exhibited disruption in HPA-axis signaling and PTSD behavioral deficits such as exaggerated fear memory recall and anxiety-like behavior even one month after being subjected to RUS. These behaviors are similar to those in humans, suggesting this model is suitable for examining the mechanisms behind fear-related abnormalities in PTSD.
 

OUR DetectX® CORTICOSTERONE ELISA KIT, K014-H/H5

  • Multi-format kit allows for measurement of Corticosterone in as little as 2 μL 
  • Validated in serum, plasma, saliva, urine, fecal extracts, and tissue culture media across a variety of species
  • Enough reagents for 37 or 229 samples in duplicate
  • Sensitivity of 20.9 pg/mL in 50 μL format and 17.5 pg/mL in 100 μL format
  • Cited in over 300 publications

BUY NOW

OUR DetectX® CYCLIC AMP (cAMP) ELISA KIT, K019-H/H5

  • Measure cAMP in 2.5 hours
  • Validated in lysates, urine, plasma, saliva, and tissue samples across mice, humans, rabbits, and more
  • Enough reagents for 39 or 231 samples in duplicate
  • Sensitive enough to measure < 5 fmol cAMP in a sample
  • Cited in over 80 publications

BUY NOW

RELATED KITS


Corticosterone Chemiluminescent ELISA Kits
K014-C1/C5Citations


Cortisone ELISA Kits
K017-H1/H5Citations


Cortisol ELISA Kits
K003-H1/H5 – Citations


Cyclic GMP Direct ELISA Kits
K020-H1/H5 – Citations


Nitric Oxide (NO) Colorimetric Detection Kit
K023-H1Citations

SHOP ALL KITS

Subscribe to our mailing list

Sign up to our e-mail newsletter and receive updates and special offers.