Products
SAHA (Vorinostat)
SAHA (suberoylanilide hydroxamic acid, Vorinostat, Zolinza™) is a histone deacetylase (HDAC) inhibitor that binds directly to the catalytic site of the enzyme thereby blocking substrate access. Sirt activator based on…
LSD1 Polyclonal Antibody
There are two known classes of histone demethylases (HDM), differing in their reaction chemistry, coenzyme use and reaction products. Flavin-dependent HDMs act only on mono- and dimethylated lysines and produce…
5-Azacytidine
Incorporates into DNA, forming covalent adducts with cellular DNMT1, depleting enzyme activity. Induces demethylation and reactivation of silenced genes. Improves the efficiency of reprogramming of stem cells. Methyltransferases in the…
BML-210
Inhibition of histone deacetylase (HDAC) enzymes by compounds such as trichostatin A can have wide ranging effects in cancer, cell differentiation, and other aspects of gene expression regulation. BML-210 is…
BML-278
Sirt activator based on a dihydropyridine structural scaffold. EC150 (effective concentration able to increase enzyme activity by 150%) is 1 uM for Sirt1, 25 uM for Sirt2, and 50 uM…
Hexyl-4-pentynoic acid (HPA)
…hyperacetylation of core histone 4 in treated F9 Cells, and one of the lowest concentrations of half-maximum effect in HDAC enzyme inhibition assays. Inhibits HDAC activity with an IC50 of…
Dimethyl Lys4 Histone H3 Polyclonal Antibody
…both transcriptional activation and silencing. Methylation of these lysine residues induces the recruitment of chromatin modifying enzymes containing methyl-lysine binding modules. The discovery in 2004 of the histone demethylase LSD1,…
Glutathione (GSH) DyLight® 488 Monoclonal Antibody
…hydrogen peroxide cellular levels are minimized by the enzyme glutathione peroxidase (GP) using GSH as a reductant. The oxidized GSH dimer, GSSG, is formed from GSH and peroxide by the…
Glutathione (GSH) DyLight® 549 Monoclonal Antibody
…oxidation. Harmful hydrogen peroxide cellular levels are minimized by the enzyme glutathione peroxidase (GP) using GSH as a reductant. The oxidized GSH dimer, GSSG, is formed from GSH and peroxide…
Glutathione (GSH) Monoclonal Antibody
…including the synthesis of proteins and DNA, the transport of amino acids, and the protection of cells against oxidation. Harmful hydrogen peroxide cellular levels are minimized by the enzyme glutathione…
Monomethyl Lys4 Histone H3 Polyclonal Antibody
…both transcriptional activation and silencing. Methylation of these lysine residues induces the recruitment of chromatin modifying enzymes containing methyl-lysine binding modules. The discovery in 2004 of the histone demethylase LSD1,…
Trimethyl Lys4 Histone H3 Polyclonal Antibody
…both transcriptional activation and silencing. Methylation of these lysine residues induces the recruitment of chromatin modifying enzymes containing methyl-lysine binding modules. The discovery in 2004 of the histone demethylase LSD1,…
TMB Substrate
Recommended for peroxidase-based enzyme immunoassays. Upon oxidation, TMB forms a water-soluble blue reaction product that can be measured spectrophotometrically at 605 nm. Upon acidification, the reaction product becomes yellow with…
Apicidin
Potent inhibitor of histone deacetylase (HDAC) activity and proliferation. Induces cell cycle arrest at the G1 phase. At 100 nM it induces a long lasting hyperacetylation of histone H4 while…