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Tranylcypromine

Inhibitor of prostacyclin synthase1, monoamine oxidase inhibitor. Also an inhibitor of LSD1, a histone H3 demethylase (IC50>2uM). Treatment of P19 embryonal carcinoma cells with tranylcypromine resulted in global increase in…

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Trichostatin A

Trichostatin A is a potent, reversible inhibitor of histone deacetylase (HDAC) with a Ki of 3.4 nM. In human Jurkat T cells, trichostatin A arrests cell cycle progression in G1…

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Xanthohumol

Binds to the N-terminal domain of valosin-containing protein (VCP), an essential protein for autophagosome maturation. Xanthohumol inhibits the function of VCP thereby impairing autophagosome maturation and resulting in accumulation of…

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BIX-01294

BIX-01294, a diazepin-quinazolinamine derivative, is a selective,cell-permeable G9a-like protein and G9a histone lysine methyltransferase (HMTase) inhibitor (IC50 values are 0.7 and 1.7 uM respectively) that displays little or no activity…

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Donkey anti-Sheep IgG

An affinity purified Donkey Antibody to Sheep IgG,(H&L). Supplied in PBS with azide as preservative. Affinity purified on a column with covalently coupled Sheep IgG attached….

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Goat anti-Mouse IgG

An affinity purified Goat Antibody to Mouse IgG, Fc region. Supplied in PBS with azide as preservative. Affinity purified on a column with covalently coupled mouse IgG, Fc attached….

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Goat anti-Rabbit IgG

An affinity purified Goat Antibody to Rabbit IgG, Fc region. Supplied in PBS with azide as preservative. Affinity purified on a column with covalently coupled rabbit IgG, Fc attached….

News & Blog

Cholinesterases: Neurotransmitter Control Systems

02/08/2018 | Blog
...nonspecific cholinesterase enzyme that hydrolyzes many different choline-based esters. The use of AChE inhibitors as therapeutic agents and pesticides has spurred detailed investigations of cholinesterases after the initial physical characterization...
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Super Sensitive Cell Signaling Assays

11/05/2020 | News
...of cGMP and considerably simplifying previously complicated detection protocols. ACTIVATORS & INHIBITORS IBMX (P019-100MG/1GM): IBMX is a widely-used non-specific inhibitor of cyclic AMP and cyclic GMP phosphodiesterases (PDEs). By inhibiting...
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Simplify your Glutathione Measurements

08/26/2016 | News
...gamma-carboxylic acid of glutamic acid to cysteine by the enzyme gamma-glutamylcysteine synthase to form gamma-glutamylcysteine. This is followed by the addition of glycine to the C-terminus of gamma-glutamylcysteine via the...
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